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題 名 | Respiratory Effort and Ventilatory Drive in Obstructive Sleep Apnea=阻塞性睡眠窒息症候群(OSAS)之呼吸使力(Respiratory Effort)及通氣驅動力(Ventilatory Drive) |
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作 者 | 蘇榮璋; 羅友倫; 林孟賢; 沈資益; 鄭志賢; 林鴻銓; 郭漢彬; 陳豪成; | 書刊名 | 胸腔醫學 |
卷 期 | 17:4 2002.12[民91.12] |
頁 次 | 頁331-339 |
分類號 | 415.472 |
關鍵詞 | 阻塞性睡眠窒息症候群; 呼吸使力; 通氣驅動力; Obstructive sleep apnea syndrome; OSAS; Respiratory effort; Ventilatory drive; |
語 文 | 英文(English) |
中文摘要 | 阻塞性睡眠窒息症候群(OSAS)肇因於睡眠時咽部呼吸道之重複塌陷,導致生理功能之失調。為了正確了解阻塞性睡眠窒息症候群(OSAS)病人呼吸使力(respiratory effort)及通氣驅動力(ventilatory drive)的差異,本研究比較三十二個阻塞性睡眠窒息症候群(OSAS)病人及二十四個對照組病人有關呼吸使力及通氣驅動力的差異。研究結果顯示二組病人間身體質量指數(BMI)、頸圍、及最大吐氣壓力(PEMax)有明顯差異;但有關每百毫秒口腔阻壓力(P0.1)、每分鐘通氣量的改變(△MV/△PetCO2)、及最大吸氣壓力(PIMax),則二組病人之間並無明顯差異。研究結果認為較大的身體質量指數(BMI)及頸圍,易導致較嚴重之阻塞性睡眠窒息症候群(OSAS)及較高之呼吸使力,但中樞之通氣驅動力似乎無明顯差異。 |
英文摘要 | Obstructive sleep apnea syndrome (OSAS) is a disorder characterized by the collapse of the pharyngeal airway during sleep, leading to the physiological dysfunction of OSAS. The aim of this study is to investigate the respiratory effort and ventilatory drive in patients with OSAS. We enrolled 32 adults with an AHI higher than 10, and 24 adults with an AHI less than 10, for a respiratory drive study. The OSAS patients had a higher mean AHI (28.39±3.25, n=32 vs 3.45±0.53, n=24, P<0.0001), a higher mean BMI (26.67±0.92 vs 22.99±0.85, P<0.01), and a higher mean neck circumference (NC) (40.48±0.74cm vs 37.03±0.75cm, P<0.005) than the control group. In addition, the AHI was significantly correlated with BMI (r=0.49, p=0.004, n=32) and NC (r=0.55, p=0.002, n=32) in the OSAS group. The PEMax was significantly higher in patients with OSAS (85.07±4.78%, n=32, p<0.05) compared with that in the control group (68.90±5.09%,n=24). However, the baseline P0.1, △P0.1/△PetCO2, △MV/△PetCO2, PIMax did not show a significant difference between the two groups. We conclude that a higher BMI and neck mass loading cause more severe OSAS and higher respiratory effort. It seems that the central respiratory drive does not intervene in OSAS. |
本系統中英文摘要資訊取自各篇刊載內容。