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題名 | Do Toplically Applied Skin Creams Containing Retinyl Plamitate Affect the Photocarcinogenecity of Simulated Solar Light?=曝曬日光下使用含Retinyl palmitate化粧品的致癌性探討 |
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作者 | Fu, Peter P.; Howard, Paul C.; Culp, Sandra J.; Xia, Qingsu; Webb, Peggy J.; Blankenship, Lonnie R.; Wamer, Wayne G.; Burcher, John R.; | 書刊名 | 藥物食品分析 |
卷期 | 10:4 2002.12[民91.12] |
頁次 | 頁262-268 |
分類號 | 412.36 |
關鍵詞 | 棕櫚酸視黃酯; 光致毒性; SKH-1裸鼠; Retinyl palmitate; Photocarcinogenicity; SKH-1 mice; |
語文 | 英文(English) |
中文摘要 | 以Retinyl Palmitate為成分之化粧品很多,然而經由日光照射後是否產生毒性及光致癌效應,目前尚未有相關報告。美國FDA (Food and Drug Adminstration) 之毒理研究中心針對含有棕櫚酸視黃酯 (Retinyl Palmitate) 之化粧品,以動物模式進行有系統的致癌效應研究並對其基本藥理毒性深入探討。棕櫚酸視黃酯 (全-反-棕櫚酸視黃酯;RP) 係2001年由美國藥物食品管理局食品安全與應用營養中心 (CFSAN) 所成立國家毒理研究中心 (NCTR) 執行之國家毒性研究計畫 (NTP) ,列為高優先進行光毒性及光致癌性研究之化合物。研究係以SHK-l裸鼠塗抹棕擱酸視黃酯後,測試模擬太陽光與紫外線是否會增強其光毒性及光致癌性,有關致毒機制之研究提供能深入了解棕擱酸視黃酯於體外及老鼠皮膚試驗之素質。 |
英文摘要 | Retinyl palmitate (all-trans-retinyl palmitate; RP) was nominated in 2001 by the U.S. Food and Drug Administration’s Center for Food Safety and Applied Nutrition (CFSAN) to the National Toxicology Program (NTP) as a high priority compound for phototoxicity and photocarcinogenicity studies at the National Center for Toxicological Research (NCTR). Studies with SKH-1 hairless mice are required to test whether topical application of RP enhances the phototoxicity and photocarcinogenicity of simulated solar light and UV light. Mechanistic studies are needed to provide insight into the disposition of RP in vitro and on the skin of mice, and to test thoroughly whether genotoxic damage by UV-induced radicals may participate in any toxicity of topically applied RP in the presence of UV light. |
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