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頁籤選單縮合
題名 | Skin Necrosis Following a Recombinant Interferon-beta-1b Injection=干擾素β-1b皮下注射引起的皮膚潰瘍 |
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作者 | 楊志勛; 陳建勳; 曾興隆; | 書刊名 | 長庚醫學 |
卷期 | 25:11 2002.11[民91.11] |
頁次 | 頁774-777 |
分類號 | 415.828 |
關鍵詞 | 干擾素β-1b; 多發性硬化症; 皮膚潰瘍; Interferon beta-1b; Multiple sclerosis; Skin necrosis; |
語文 | 英文(English) |
中文摘要 | 皮下注射干擾素β-1b已經證實可以有效緩解反復發作型的多發性硬化症病患。此藥物治療的原理尚未明瞭,但有可能是經由抗病毒或免疫調節的機轉。干擾素β-1b注射最常見的副作用包括了發燒,疲倦,肌肉酸痛,嘔心等類似感冒的症狀。皮膚潰瘍的不良反應在過去報告中並不常見,而且大多數是單一的小型潰瘍。我們報告一例患有多發性硬化症的病患在接受了干擾素β-1b皮下注射後,在四肢注射處產生多處大範圍的皮膚潰瘍。這些皮膚潰瘍最後採用手術切除及縫合。由於在病理切片下可以發現位於皮下脂肪層的血管阻塞,以及臨床上在皮膚潰瘍週圍呈現廣泛紅斑,我們推斷干擾素β-1b注射後引起局部的血管病變造可能是造成皮膚潰瘍的原因。 |
英文摘要 | Recombinant interferon beta-1b (INF-β-1b) has been proven to be an effective means of treating relapsing-remitting multiple sclerosis(MS). Adverse reactions to interferon therapy have been well documented. The most common side effects are transient influenza-like symptoms, including fever, fatigue, nausea, and myalgia. Cutaneous necrosis has occasionally been reported, mostly involving small and limited lesions. This article describes an MS patient who developed multiple large, deep cutaneous ulcers on INF-β-1b injection sites, which subsequently required surgical treatment. Vessel thrombosis in the subcutaneous fatty layer and the clinical appearance of livedoid erythema beside the ulcers indicated that INF-β-1b may have caused skin necrosis through its cascular effects. |
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