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頁籤選單縮合
題名 | Correlation of Two Widely Used Psychiatric Rating Scales in Patients with Schizophrenia=兩種常用精神科量表於精神分裂症患者之相關性研究 |
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作者 | 藍先元; 鄭光男; 張聖莉; 蕭英桃; 呂秀珠; Lane, Hsien-yuan; Cheng, Kawn-nan; Chang, Sheng-li; Hsiao, Ying-tao; Lu, Hsiu-chu; |
期刊 | 慈濟醫學 |
出版日期 | 20020800 |
卷期 | 14:4 2002.08[民91.08] |
頁次 | 頁213-218 |
分類號 | 415.983 |
語文 | eng |
關鍵詞 | 臨床整體印象; 活性與負性症狀量表; 精神分裂症; Clinical global impression; Positive and negative syndrome scale; Schizophrenia; |
中文摘要 | 目的:臨床整體-嚴重度(Clinical Global Impression-Severity, CGI)是一種整體性、僅有一個評量項目的精神科評量表。我國中央健康保險局已建議採用本量表作為臨床上評估精神病患之工具。活性與負性症狀量表(Positive and Negative Syndrome Scale, PANSS)則是一種具有30個項目、完整的精神症狀評量表,且具有良好的信度。本研究針對一個大樣本精神病患以嚴謹統計方法分析CGI與PANSS分數之相關性。病人與方法:121位新住院的急性發作精神分裂症病患進入這個為期六週、重覆施測的前瞻性研究。患者每兩週接受一次CGI與PANSS之臨床評估。我們將PANSS總分取對數,使之呈現常態分佈,以作為迴歸分析的依變項。我們的目的是評估CGI分數對PANSS總分的影響效應,但為了控制其他臺能的自變項以及重覆施測造的影響,我們以一種名為概括性估計等式(generalized estimating equation)迴歸分析法進行分析。結果:於研究期間CGI與PANSS分數皆逐漸降低。經由調整其他變項以重覆施測的影響,CGI每升高1分則PANSS總分平均上升16.5%(p<0.001),此外,患者以往往院時間每增加1週,PANSS總分也平均上升0.02%(p<0.001)。至於其他臺能的自變項則對PANSS總分沒有顯著的影響。結論:本研究結果顯示急性發傷的精神分裂症住院病患的CGI分數與PANSS總分呈顯著相關性。據我們所知,這是世界上首次的報告,具有臨床上重要意義,當然,未來仍須更多研究予以進一步確認,特別是針對其他的族群,例如慢性或門診病患。 |
英文摘要 | Objective: The Clinical Global Impression-Severity (CGI), a global psychiatric assessment scale with only one rating item, has been recommended by our Central Health Insurance Bureau for evaluating mentally-ill patients in clinical settings. This study, utilizing rigorous statistics in a large psychiatric population, investigated the correlation of scores of the CGI and the Positive and Negative Syndrome Scale(PANSS), a comprehensive psychiatric rating scale with 30 items and adequate reliability. Patients and Methods: One hundred and twenty one newly hospitalized schizophrenia patients with acute exacerbation entered this prospective 6-week repeated measures study. Clinical assessments were conducted biweekly with the CGI and PANSS. The logarithms of PANSS total scores were selected to serve as the outcome values because they were normally distributed and thus suitable for regression analyses. To determine the effects of CGI scores on outcome values, generalized estimation equation methods were utilized to adjust the effects of other possible prognostic factors and take into account the within-subject dependence over repeated assessments. Results: Both CGI and PANSS scores declined gradually during the study period. After adjusting the effects of the study duration and other variables, each score increase in the CGI raised the total PANSS score by 16.5% on average (p<0.0001). In addition, every 1-week increment in poior hospitalization duration also increased the total PANSS score by 0.02% (P<0.0001). Other possible prognostic factors did not significantly influence the outcome value. Conclusion: The results suggest that CGI scores are significantly relate to PANSS total scores in acutely ill schizophrenia inpatients. To our knowledge, this is the first study revealing this correlation and it has important clinical implications. Further studies are warranted, particularly for other populations such as chronically ill patients or outpatients. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。