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題 名 | 維生素D類似物的臨床新境界=New Perspectives of Vitamin D Analogues in Clinical Therapy |
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作 者 | 馮祥華; | 書刊名 | 內科學誌 |
卷 期 | 13:4 2002.08[民91.08] |
頁 次 | 頁167-174 |
分類號 | 418.2184 |
關鍵詞 | 繼發性副甲狀腺亢進症; 維生素D類似物; 臨床治療應用; Secondary hyperparathyroidism; Vitamin D analogues; Clinical therapy; |
語 文 | 中文(Chinese) |
中文摘要 | 文獻上治療繼發性副甲狀腺亢進症的藥物,在過去五年來已經明顯的有所改變,但是在臺灣的臨床醫界則似乎尚未起步。目前研究的重點在恢復維持骨質的完整性,以及心臟功能的良好狀態,此二者對長期透析患者的完整醫療照護和良好預後都是重大的因素。新的治療發展,尤其是無鈣無鋁的磷酸鹽結合劑與維生素D類似物,都針對患者骨質的健康及心臟血管系統的維護,提供更優良的療效。有許多新的維生素D類似物已經成熟或正在進行研發,它們的潛在臨床治療效用很廣,例如治療高度增生疾病、免疫功能失調、內分泌異常及代謝性骨病變等。新發展的維生素D類似物保有許多活性維生素D的治療特性,但是在提升血鈣濃度與副作用上則較低。因此許多維生素D類似物被用來試驗治療各種不同的癌症、骨質疏鬆症、自體免疫疾病甚至器官移植的抗排斥。現代的醫師應該了解維生素D的選擇治療作用,以便在不久的將來可用以治療更寬廣的臨床疾病。 |
英文摘要 | The treatment of secondary hyperparathyroidism has changed significantly over the last 5 years, but no definite change in clinical field was noted, especially in Taiwan. Recent studies have concentrated on bone integrity and cardiac status as conditions that require adequate management to improve patient care and outcomes in chronic dialysis population. Additionally, new developments in therapies for secondary hyperparathyroidism, including noncalcemic phosphate binders and vitamin D analogues, provided superior management for both the bone health and cardiovascular perspectives. Numerous analogues have been studied and developed. This review provides review of vitamin D analogues along with their specific therapeutic uses. The breadth and magnitude of activities of these vitamin D analogues suggest potential therapeutic applications for the treatment of several diseases and disorders, including hyperproliferative diseases, immune dysfunction, endocrine disorders, and metabolic bone diseases. Newly developed vitamin D analogues with lower calcemic activity have been shown to retain many therapeutic properties of calcitriol. Several analogues are currently being tested in preclinical and clinical trials for the treatment of various types of cancer, osteoporosis, autoimmune disease and transplant rejection. Understanding how vitamin D exert their selective actions may allow for the treatment of a wide range of clinical disorders in the near future. |
本系統中英文摘要資訊取自各篇刊載內容。