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| 題 名 | Classical Kaposi's Sarcoma of the Glans Penis Effectively Treated with Low-dose Intralesional Vinblastine Injection--A Case Report=以低劑量Vinblastine病灶內注射有效地治療龜頭之傳統卡波西肉瘤--病例報告 |
|---|---|
| 作 者 | 李淑芬; 王德華; 李玉雲; | 書刊名 | 中華皮膚科醫學雜誌 |
| 卷 期 | 20:3 2002.09[民91.09] |
| 頁 次 | 頁218-222 |
| 分類號 | 415.78 |
| 關鍵詞 | 低劑量; 龜頭; 卡波西肉瘤; Kaposi's sarcoma; Vinblastine; Glans penis; |
| 語 文 | 英文(English) |
| 中文摘要 | 傳統卡波西肉瘤為一可侵犯皮膚及內臟器官之多發性惡性血管腫瘤,通常好發在年紀較大的病人、免疫力低下者或同性戀者。雖然發生在生殖器之卡波西肉瘤並不罕見,但對位於龜頭部位之多發性卡波西肉瘤在治療上則有其特殊的老量及困難處。一般而言,局部之卡波西肉瘤可以用手術切除、放射線治療、冷陳治療、及病灶內注射干擾素或其他化學藥物等來治療。雖然病灶注射vinblastine對位於口腔之卡波西肉瘤的治療效果極佳,但此種治療方式對位於龜頭之卡波西肉瘤的療效如可則未知。本文報告用此方法治療一例局限於龜頭之傳統卡波西肉瘤的治療經驗。病人於西部麻醉後,接受每兩週一次、共六次病灶內注射vinblastine(濃度為每毫升0.2毫克,每次注射1毫升);病灶在托受一次治療後,即縮小70%,而在連續四次治療後即幾乎完全消失。治療過程中並無明顯的副作用出現,之後追蹤十八個月並無復發現象。鑑於此病例之治療經驗,病灶內注射低劑量vinblastine可能是治療龜頭部位之卡波西肉瘤的另外一種好的療法。 |
| 英文摘要 | Classical Kaposi’s sarcoma (KS) is a multicentric cutaneous and extracutaneosu vascular neoplasm predominantly affecting older individuals, immunosuppressed patients and homosexual men. Although KS of the genitalia is not rare event, it is challenging to treat multiple KS of the glans penis. Localized KS may be treated by excision, radiation, cryotherapy and intralesional injection of interferon-alpha or cytotoxic chemotherapy. Although intralesional injection of vinblastine has beenused to treat oral KS successfully, little is known about its efficacy in treating glanular KS. We report a 56-year-old man with isolated, classical KS involving his glans penis. The tumors were treated with 6 biweekly intralesional vinblastine injections (0.2 mg/ml, 1 ml/dose) after regional anesthesia. The tumors showed about 70% reduction in size after one injection and were almost completely resolved after 4 treatments. There was no obvious side effect. The patient remained tumor-free 18 months later. The favorable response in our case suggests that intralesional low-dose vinblastine injection could be an effective alternation for treating glanular KS. |
本系統中英文摘要資訊取自各篇刊載內容。