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題名 | 以噬血症候群表現的惡性淋巴瘤同時合併急性巨大細胞病毒感染--一病例報告=Lymphoma-associated Hemophagocytic Syndrome with Acute Cytomegalovirus Infection--A Case Report |
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作者 | 王銘崇; 郭景元; 刑福柳; | 書刊名 | 內科學誌 |
卷期 | 13:2 2002.04[民91.04] |
頁次 | 頁104-108 |
分類號 | 415.6 |
關鍵詞 | 惡性淋巴瘤; 噬血症候群; 巨大細胞病毒感染; Malignant lymphoma; Hemophagocytic syndrome; Cytomegalovirus infection; β[feaf]-microglobulin; |
語文 | 中文(Chinese) |
中文摘要 | 一36 歲女性病患 , 因發燒一週住院 , 檢查發現有黃痘、肝脾腫大、血球下降及 雙側性肺炎 , 診斷為急性巨大細胞病毒感染 , 骨髓檢查證實為噬血症候群 ; 並以 巨大細胞病毒藥物 (Gancyclovir) 治療 , 肺炎明顯改善 , 但仍持續發燒、肝脾腫 大、黃痘。經肝臟切片檢查證實為 T- 細胞淋巴瘤。噬血症候群的死亡率相當高 , 致病成因包括感染、惡性腫瘤、自體免疫疾病及家族性。而本病例同時併有病毒 感染及惡性淋巴瘤以噬血症候群來表現則甚為罕見。 |
英文摘要 | A 36-year-old female patient was admitted due to fever for one week. Serial studies showed that she had jaundice, marked hepatosplenomegaly, severe pancytopenia and bilateral interstitial pneumonitis. Specific cytomegalovirus IgM antibody was positive, and bone marrow aspiration smear showed hemophagocytosis without malignant cells infiltration. It was an improvement in interstitial pneumonitis after Gancyclovir treatment, but she had a persistent fever, hepatosplenomegaly and jaundice. Therefore liver biopsy was performed and T-cell lymphoma was diagnosed. Hemophagocytic syndrome is an extremely fetal disorder. The causes include infection, malignant tumor, autoimmune disease and familial origin. This patient had acute CMV infection-associated and malignant lymphoma-associated hemophagocytic syndrome simultaneously. It is very rare. ( (J Intern Med Taiwan 2002;13:104 -108 ) |
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