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題 名 | Design and Fabrication of Multi-microelectrode Array for Neural Prosthesis=設計和製造運用於神經義肢之多電極陣列 |
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作 者 | 朱銘祥; 簡欣鈞; 陳景欣; 林宙晴; 張正宏; 張啟文; | 書刊名 | Journal of Medical and Biological Engineering |
卷 期 | 22:1 2002.03[民91.03] |
頁 次 | 頁33-40 |
分類號 | 410.1644 |
關鍵詞 | 神經義肢; 微電極; 神經電圖; Neural prosthesis; Microelectrode; Electroneurography; |
語 文 | 英文(English) |
中文摘要 | 我們運用微製造技術製造了神經義肢所需之平面多電極陣列。基於生物相容性的考慮,陣列的底材為矽膠、絕緣層為聚醯亞胺而導體為金。在系統設計時,我們也發展了模擬微電極特性的模型。此平面電極陣列具有十八個電極,每個電極的接觸面積為600×400μm。電極接收訊號的性能利用動物實驗來測試。我們將電極陣列放在家兔大腿之坐骨神經旁然後移動踝關節。結果顯示電極陣列可以感應踝關節移動時神經訊號的改變。離線分析發現電極所測得神經訊號與關節角度和角速度之加權總和有良好的相關性。總結,我們發展了一個平面多電極陣列,並在急性動物實驗中證實電極可以測得神經訊號。 |
英文摘要 | A multi-microelectrode system for neuroprostheses was designed and manufactured by using microfabrication technologies. For biocompatibility, we used silicone rubber as the base layer, polyimide as the insulation layer and gold as the conduction material. A model simulating the electric properties of the microelectrode array was developed for system design. The electrode system was planar and consisted of 18 microelectrodes. The contact area of each microelectrode was 600×400 µm. The sensing capability of the microelectrode system was tested in animal experiments. We put the system underneath the sciatic nerve of New Zealand rabbit and passively move the ankle joint. The results showed that the system could record changes in neural signals during movements. Analyses of the recorded signals and the joint angle revealed that the recorded neural signals had good correlation with the weighted sum of joint angle and angle velocity. In conclusion, we developed a planar multi-microelectrode system, which could sense neural signals in acute animal experiments. |
本系統中英文摘要資訊取自各篇刊載內容。