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題 名 | 臺灣族群的粒線體DNA非編碼區之核苷酸變異=Nucleotide Sequence Variability in the Major Non-coding Regions of Taiwanese Mitochondrial DNA |
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作 者 | 吳芳鴦; 李和欣; 王瑞筠; 賴俊雄; | 書刊名 | 中國醫藥科學雜誌 |
卷 期 | 1:4 2000.12[民89.12] |
頁 次 | 頁229-238 |
分類號 | 364.21 |
關鍵詞 | 粒線體DNA; D-loop領域; 種系發生; 原住民; Mitochondrial DNA; D-loop region; Phylogenesis; Taiwanese aborigines; |
語 文 | 中文(Chinese) |
中文摘要 | 本研究將粒線體DNA中最主要的非編碼區(D–loop領域)中的一段 序列(此斷片長為428bp)定序,以瞭解原住民(泰雅族、布農族、鄒族、魯凱 族、排灣族、雅美族,六族共53人)與漢族(客家人26人,閩南人38人)之 核甘酸的取代(置換)、插入、刪除等變異情形。由結果顯示在428個鹼基中, 共有63個位置(position)具有多型性。這些多型性部位屬於鹼基置換的有56 個,其中有91%是轉移(transition)置換,而1個鹼基的刪除或插入的部位有7 個。插入只發生在一個位置,亦即117個個體都在同一位置(16004)上被插入 一個T。另一方面,各族群在超可變區14個鹼基對的序列中,有9種不同的序 列被檢測到,約有85.5%之個體是AAAACCCCCTCCCC的序列。其中有1序列 的C stretch 內的鹼基置換是由T轉換成C,而這個置換造成C stretch的延長及 A stretch的減少。以特殊變異點而言,約60%(6人/11人)的泰雅族是在16086 位置由C取代T(T→C)的突變。雅美族在16129、16162及16172這三個位置 都有高比列的突變,但16129位置在閩南人(14人/38人)佔36%及客家人(10 人/26人)佔38%,鄒族(8人/10人;佔80%)及泰雅族(7人/11人;佔64%) 在這個位置也佔很高的比例。16223位置的突變較屬於閩南人(22人/38人;佔 58%)與客家人(17人/26人;佔65%)的變異。以AMOVA分析種內及種間 的變異發現來自於族群內的變異佔74.6%,而漢族與原住民間佔32.1%,具統計 上的差異(p<0.05)。由分子系統樹分析顯示泰雅族、鄒族、魯凱族有群聚(cluster) 現象。而鄒族與布農族/排灣族與魯凱族彼此間具有較強的類緣關係。 |
英文摘要 | Nucleotide sequences of the D-loop region of human mitochondrial DNA (mtDNA) from 53 aborigines (including 11 Atayal, 10 Bunun, 10 Tsuo, 7 Rukai, 6 Paiwan, 9 Yami) and 64 Hans (including 38 Fuchienese and 26 Kwangtungese) have been determined. These sequences include at least a 428bp long region encompassing most of the D-loop-forming region. Comparisons of these sequences with those previously determined have revealed remarkable features of nucleotide substitutions, insertion and deletion events. We found mutations at a total of 63 sites on a 428bp fragment. In the whole data, transition types of substitution are more predominant than transversions; that is, 91% are transitions while only 9% are transversions. We also observed both deletion at 14 sites and insertion of T at one sites. A hypervariable region has also been defined. In this 14-base region, 9 different sequences were detected. About 85.5% of individuals exhibit the sequence, which contains a 14-base stretch of AAAACCCCCTCCCC. One of nine sequences resulted from elongation of the C stretch and shortening of the A stretch. 60% Atayal has the T at position 16086 is replaced by C. Yami has significantly the nucleotide changes at position 16129, 16162, and 16172. The nucleotide variance at position 16129 is estimated as 36-38% on Fuchienese and Kwangtungese. Moreover, the AMOVA results are shown that the variance more similar within racial groups (74.6%) than among racial groups (32.1%). The phylogenetic analysis indicates the cluster on Atayal, Tsuo and Rukai. There is a high correlation between Tsuo and Bunun, as well as Paiwam and Rukai. |
本系統中英文摘要資訊取自各篇刊載內容。