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頁籤選單縮合
題名 | Tumor Invasion and Metastasis=癌症轉移 |
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作者姓名(中文) | 陳紀雄; | 書刊名 | 慈濟醫學 |
卷期 | 14:1 2002.02[民91.02] |
頁次 | 頁1-5 |
分類號 | 415.138 |
關鍵詞 | 癌症轉移; Metastasis; Extracellular matrix remodeling; Epithelial mesenchymal transition; |
語文 | 英文(English) |
中文摘要 | 癌症的死亡大都是由於對轉移癌細胞的治療失敗所致,因而研究癌症 轉移機制已成為研究癌症的終極目標,在此review我們簡單討論,就我們現今 所知癌細胞經由(1)活化epithelial mesenchymal transition(EMT),(2) extracellular matrix(ECM)的remodeling及(3)癌細胞由原位轉移到特定的器官等三種機制完成 癌細胞轉移。由我們及其他研究同儕的研究結果顯示,屬於ETS群的轉錄因子 在活化EMT及ECM remodeling扮演重要的角色,因此研究在這三種轉移機制的 調控,將有助於了解癌細胞如何由良性腫瘤變成轉移性癌細胞的過程中,基因及 epigenetic的變化。(慈濟醫學2002; 14:1-5) |
英文摘要 | Most cancer deaths are attributed to the failure of response to treatment of migrating tumor cells. Thus investigation of the mechanisms of tumor invasion and metastasis has become the last frontier of cancer research. Here we briefly discuss how benign cancer cells, through well orchestrated mechanisms of (a) activation of epithelial mesenchymal transition (EMT), (b) remodeling of extracellular matrix (ECM), and (c) migration of cancer cells to distant specific sites, turn into metastatic cancer cells. From the experimental observations by us and others we know that members of the ETS transcription factor family play important roles in activating genes encoding proteins responsible for EMT and ECM remodeling. Thus studies into the regulatory mechanisms of these three events will help trace the genetic and epigenetic changes that turn a benign cancer cell into a malignant migrating one. (Tzu Chi Med J 2002; 14:1-5) |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。