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題名 | 一種中樞調節食慾的物質--纖瘦素=Leptin: A Centrally-Active Mediator of Feeding Behavior |
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作者姓名(中文) | 廖美齡; 傅任巧; 施承典; | 書刊名 | 大仁學報 |
卷期 | 20 2001.06[民90.06] |
頁次 | 頁1-15 |
分類號 | 418.21 |
關鍵詞 | 肥胖; 纖瘦素; 神經內分泌; 抗肥胖荷爾蒙; Obesity; Leptin; Neuropeptides; Neuroendocrine; Antiobesity hormone; |
語文 | 中文(Chinese) |
中文摘要 | 肥胖的人口在全球各地有增加的趨勢,近來更與多種常見疾病的致病率及致死率及其相關,如糖尿病、高血壓、心血管疾病及癌症等。雖然因肥胖導致疾病的案例日益漸增,但其主要致病的原因目前依舊未明,直到五年前一種與肥胖有關之荷爾蒙-纖瘦素的發現,才對肥胖之病因有進一步的瞭解。纖瘦素是一種由167個胺基酸組成的荷爾蒙,在脂肪細胞中製造與分泌。血液中的的纖瘦素含量不僅反映出身體的總脂肪量,亦反映體內能量的不平衡以及幾種細胞激素和荷爾蒙之血中濃度。纖瘦素從脂肪組織分泌後,經血液循環送至腦部,作用於腦內下視丘的纖瘦素接受器上,並且調節幾種神經調節物質的活性,進而抑制食慾,使食物攝取量減少及脂肪細胞能量消耗增加。因此,纖瘦素在肥胖與飲食疾病的病因上扮演重要的角色。不僅如此,更多的證據顯示纖瘦素除了是一種抗肥胖的荷爾蒙之外,事實上亦具有非常多的作用,其中包括可調控許多神經內分泌機制及生理功能。 在本文簡短的回顧中,我們將介紹目前纖瘦素在人體其他系統中的生理及病理作用。並且也進一步就由對人體能量平衡以及體重控制的瞭解,探討纖瘦素未來可能的治療用途。 |
英文摘要 | Obesity, the prevalence of which has been progressively increasing worldwide, is closely associated with increased morbidity and mortality caused by several of the most common diseases in the world, including diabetes, hypertension, cardiovascular diseases, and cancer. The pathogenesis of obesity remains largely unknown, but research on its pathophysiology has recently intensified, largely because of the discovery of leptin 5 years ago. Leptin contains 167 amino acids that is expressed and secreted exclusively from adipocytes, Serum levels of leptin reflect the amount of energy stored in adipose tissue. Short-term energy imbalance as well as serum levels of several cytokines and hormones influence circulating leptin levels. Leptin acts by binding to specific receptors in the hypothalamus to alter the expression of several neuropeptides that regulate neuroendocrine function and energy intake and expenditure. Thus, leptin plays an important role in the pathogenesis of obesity and eating disorders. However, accumulating evidence suggests that the role of leptin is much broader than that of an antiobesity hormone; leptin also affect several neuroendocrine mechanisms and regulates multiple physiologic functions. In this brief review, we present the current understanding of leptin's role in various physiologic and pathophysiologic states in human. We also discuss the potential therapeutic implications of the advanced knowledge on energy homeostasis and body weight regulation. |
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