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題名 | Prevention of PONV with Dexamethasone in Female Patients Undergoing Desflurane Anesthesia for Thyroidectomy=Dexamethasone對女性患者在接受 Desflurane 麻醉及甲狀腺切除術後預防噁心及嘔吐的效果 |
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作者 | 李毅; 林佩金; 賴賢勇; 黃顯哲; 林祐生; 鄭清榮; | 書刊名 | 麻醉學雜誌 |
卷期 | 39:4 2001.12[民90.12] |
頁次 | 頁151-156 |
分類號 | 416.5 |
關鍵詞 | 噁心嘔吐; 甲狀線切除術; Dexamethasone; Desflurane; Nausea and vomiting; Thyroidectomy; |
語文 | 英文(English) |
中文摘要 | 背景:報告顯示病人使用desflurane麻醉後,比使用isoflurane或sevoflurane有較高的比率會產生噁心和嘔吐.先前研究證明給予dexamethasone於使用isoflurane麻醉進行甲狀腺切除術的女性患者,其預防噁心嘔吐最低有效劑量為5毫克.本研究觀察麻醉誘導前給予dexamethasone8毫克,5毫克以及生理食鹽水,在女性患者使用desflurane麻醉進行甲狀腺切除術後,對於噁心嘔吐的預防效果. 方法:一百三十五名預備進行甲狀腺切術的女生病人隨機分成三組.於麻醉誘導前分別靜派給予dexamethasone 8毫克(D8組),dexamethasone 5毫克(D5組),和生理食鹽水(S組)。結果:Dexamethasone 8毫克及5毫克都可以降低術後噁心嘔吐以及使用止吐劑的機率,然而D8和D5組互相比較時,術前使用dexamethasone 8毫克的病人在術後24小時內不發生嘔吐及不需接受止吐劑的比率比使用dexamethasone 5毫克的病人高(86%vs.67%;P<0.01)。結論:對於使用dexflurane麻醉進行甲狀腺切除術的女性病人,于麻醉誘導前靜派給予dexamethasone 8毫克,可以提供比dexamethasone 5毫克更有效的預防術後噁心嘔吐的效果。 |
英文摘要 | Background: Desflurane is associated with a higher incidence of 24-h postoperative nausea and vomiting (PONV) as compared with sevoflurane or isoflurane. Dexamethasone 5 mg i.v. is suggested to be the minimum effective dose for prophylaxis ofPONV in women undergoing thyroidectomy with isoflurane anesthesia. The objective of this study was to investigate whether a 5mg dose of dexamethasone could be enough for; or a larger dose at 8 mg, could be more capable of preventing PONV in women undergoing desfiurane anesthesia for thyroidectomy. Methods: One hundred and thirty five patients were assigned to receive one of three treatment regimens prior to induction i.e., dexamethasone 8mg i.v. (Group D8), dexamethesone 5mg i.v. (Group D5) or saline (Group S). Results: It was demonstrated that the prophylactic administration of either dexamethasone 8mg or 5mg significantly reduced the overall incidence of PONV in patients undergoing thyroidectomy with desfiurane anesthesia P<0.001, Group D8 vs. Group S; Group D5 vs. Group S). Howevet; patients who received dexamethasone 8mg showed a higher incidence of complete responses (no vomiting or need of rescue antiemetic medication for a 24-h postoperative period) in comparison with those receiving dexamethasone 5mg (86% vs.67%; P<0.01). Conclusions: The results of this study showed that in PONV prophylaxis, in female patients undergoing desflurane anesthesia for thyroidectomy, the effect of dexamethasone 8mg was superior to that of dexamethasone 5mg. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。