頁籤選單縮合
題 名 | Cytotoxic Triterpenes from the Fruit of Ziziphus Jujuba |
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作 者 | 黃瑞齡; 王婉儀; 郭悅雄; 林雲蓮; | 書刊名 | 中華藥學雜誌 |
卷 期 | 53:4 2001.08[民90.08] |
頁 次 | 頁179-184 |
分類號 | 414.33 |
關鍵詞 | Ziziphus jujuba; Triterpenes; Cytotoxicity; |
語 文 | 英文(English) |
英文摘要 | Four triterpenes, zizyberenalic acid (1), oleanonic acid (2), ursolonic acid (3), and betulonic acid (4), were isolated from the fructus of Ziziphus jujuba Mill as active principles against the viral producing hepatoma cell line MS-G2. Their structures were elucidated by 2D-NMR spectroscopy. All of the compounds displayed anti-HBsAg and anti-HBeAg activity against MS-G2 cells. The EC50 values against HBsAg and HBeAg were 22.3 ± 0.6 and 19.3 ± 1.2 mM, 18.1 ± 1.2 and 18.3 ± 0.6 mM, 23.5 ± 1.5 and 25.9 ± 3.7 mM, and 4.7 ± 1.1 and 4.5 ± 0.3 mM, respectively, for compounds 1, 2, 3, and 4. However, cytotoxic effects were found at higher concentrations with IC50 values of 41.9 ± 5.3, 55.2 ± 13.2, >100, and 71.7 ± 16.9 mM, respectively. |
本系統中英文摘要資訊取自各篇刊載內容。