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題名 | In Vitro Adsorption of Basic Drugs on the Mucoprotective Agent Smecta=胃腸黏膜保護劑思密達對鹼性藥品之體外吸附 |
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作者 | 鄭靜玲; 周辰熹; | 書刊名 | 嘉南學報 |
卷期 | 27 2001.11[民90.11] |
頁次 | 頁106-112 |
分類號 | 418.24 |
關鍵詞 | 吸附; 胃腸黏膜保護劑; 思密達; Adsorption; Disopyramide; Mucoprotective agent; Quinidine; Smecta; |
語文 | 英文(English) |
中文摘要 | 思密達(雙八面蒙脫石)為一天然之吸附性土石,用於易刺激性腸道綜合症及胃 食道逆流之症狀治療。它亦可用於治療急、慢性腹瀉。思密達對許多藥物,特別是鹼性藥物 ,具有很強之吸附力。 本研究中探討思密達對 disopyramide 及 quinidine 這兩個鹼性藥 物在體外 pH 4.5 磷酸緩衝溶液中之吸附情形,藉以評估其在體內藥物交互作用之可能性。 結果顯示在臨床使用劑量下思密達對 disopyramide 之吸附力很強, disopyramide 被吸附 之比例在低( 40 μ g/mL )、高( 400 μ g/mL )濃度分別為 98.32 及 96.49 %。 而 思密達對 quinidine 之吸附力亦很強, quinidine 被吸附之比例在低( 80 μ g/mL )、 高( 800 μ g/mL )濃度分別為 99.99 及 99.88 %。 由於思密達對 disopyramide 及 quindine 之吸附力很強, 可能會造成其吸收速率及程度之下降,因此這兩個鹼性藥物應該 避免同時與思密達共服。根據文獻與本研究之結果,思密達應避免與鹼性藥物同時服用,如 需服用其他藥物,建議與思密達間隔一段時間。 |
英文摘要 | Smecta, dioctahedral smectite, is a natural adsorbent clay used for symptomatic treatment of irritable bowel syndrome and gastroesophageal reflux. It is also used for acute and chronic diarrhea. Smecta is known to adsorb avidly certain compounds, especially basic drugs. In this study, the extent of adsorption of two basic drugs disopyramide and quinidine onto Smecta was determined in vitro at pH4.5 phosphate buffer solution, in order to predict the potential for in vivo drug-drug interactions. For disopyramide, the extent of adsorption onto therapeutic dose of Smecta was very high at both of the concentrations tested, with mean values of 98.32 ± 0.10 (S.D., n=3) and 96.49 ± 0.17% at concentration of 40 and 400 μ g/mL (disopyramide phosphate), respectively. For quinidine, the extent of adsorption was also very high at both of the concentrations tested, with mean values of 99.99 ± 0.004 (S.D., n=3) and 99.88 ± 0.01% at concentration of 80 and 800 μ g/mL (quinidine sulfate), respectively. Because both disopyramide and quinidine are significant adsorbed by Smecta, which may decrease their rate and/or extent of absorption in vivo, they should not be co-administered with Smecta. Based on literature and the present results, it is recommended not to administer any other basic drugs at the same time as Smecta. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。