查詢結果分析
來源資料
頁籤選單縮合
題 名 | Determination and Disposition Kinetics of Phellamurin Metabolites in Rat Brain=黃柏素-7-葡萄糖苷之代謝物在大白鼠腦中之分析及動力學 |
---|---|
作 者 | 陳鴻儀; 吳天賞; 侯鈺琪; 郭盛助; 李珮端; | 書刊名 | 藥物食品分析 |
卷 期 | 9:3 2001.09[民90.09] |
頁 次 | 頁127-131 |
分類號 | 414.33 |
關鍵詞 | 黃柏素--7--葡萄糖苷; 新黃柏素; 新黃柏素葡萄糖醛酸; 腦中分析; Phellamurin; Neophellamuretin; Neophellamuretin glucuronides; Brain distribution; |
語 文 | 英文(English) |
中文摘要 | 黃柏素-7-葡萄糖��是臺灣黃蘗的樹葉中含量頗豐的一種雙氫黃酮類配醣體。本研究探討黃柏素-7-葡萄糖��之代謝物在大鼠腦中之動力學。大鼠口服100 mg/kg和200mg/kg 兩種劑量,於給藥後0.33,2,4及6小時將大鼠犧牲,分析腦中黃柏素-7-葡萄糖��之代謝物。 定量方法係採用高效液相層析法,檢測腦組織經β-葡萄糖醛酸�t水解之前及之後所含新黃柏素之濃度。移動相為乙�禲G水(含1%醋酸,38:62,v/v)。結果顯示新黃柏素葡萄糖醛酸可能穿越血腦障蔽,其腦中之濃度呈劑量相關性,而新黃柏素在腦中的含量則極微。 |
英文摘要 | Phellamurin is a flavanone glycoside that is abundant in the leaves of Phellodendron wilsonii Hayata et Kanehira (Rutaceae). The disposition kinetics of phellamurin metabolites in rat brain was investigated in this study. Doses of 100 mg/kg and 200 mg/kg were orally administered to rats. At 0.33, 2.4 and 6 hr after dosing, rats were dissected and the brain concentrations of the aglycone neophellamuretin were determined by an HPLC method prior to and after hydrolysis with β-glucuronidase. The mobile phase was acetonitrile: HO�� (containing 1% acetic acid, 38: 62. v/v). Our results indicated that neophellamuretin glucuronide might be able to cross the blood-brain barrier and its concentration in the brain was does-dependent at the two doses investigated, whereas the aglycone neophellamuretin was present in a trace amount in the brain. |
本系統中英文摘要資訊取自各篇刊載內容。