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題 名 | Apolipoprotein E Polymorphism and Alzheimer's Disease=ApoE多形性狀與阿滋海默病之相關性 |
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作 者 | 顏永杰; 劉景寬; 龍佛衛; 張明永; | 書刊名 | The Kaohsiung Journal of Medical Sciences |
卷 期 | 17:4 2001.04[民90.04] |
頁 次 | 頁190-197 |
分類號 | 415.8471 |
關鍵詞 | 阿滋海默病; ApoE基因; Alzheimer's disease; Apolipoprotein E; Polymorphism; |
語 文 | 英文(English) |
中文摘要 | 本研究之目的在探討ApoE基因型與阿滋海默病在臨床表現的相關 性,期能提供臨床工作者參考。本研究50名研究組個案符合NINCDS-ADRDA 之「確定為阿滋海默病」或「可能為阿滋海默病」之標準,及DSM-IV診斷準則 中阿滋海默病之標準;50名對照組個案則依性別、年齡收案;每一個案均接受 會談評估及ApoE基因型分析。研究結果發現兩組個案均為女性28人、男性22 人,平均年齡、受教育年資等無顯著差異。研究組的平均發病年齡為72.62歲, 平均發病時間為3.85年。研究組之 ApoEε4基因出現頻率明顯高於對照組 (分別 為0.13及,p<0.005)。有ApoEε4基因的人比沒有ApoEε4基因的人罹患阿滋海 默病之勝算比為6.0 (95%CI:1.34~55.3;p<0.001);ApoEε4基因之出現與罹患阿 滋海默病有明顯相關性 (?2=83,p=0.004)。ApoEε4基因在晚發型阿滋海默病、 男性及低教育程度者的罹病機會,比早發型阿滋海默病、女性及高教育程度者更 高。將ApoEε4基因之有無作為阿滋海默病診斷依據時,其敏感度為24%,特定 度為96%,陽性預測值為86%,陰性預測值為56%。ApoEε4基因與阿滋海默病 有關,性別與教育程度可能影響阿滋海默病的發生;此外,ApoEε4基因也可作 為阿滋海默病診斷的輔助工具。 |
英文摘要 | We aimed to determine the association and related factors of the apolipoprotein E (ApoE) genotype and Alzheimer,s disease (AD) in Taiwan. We examined ApoE genotypes in 50 Chinese patients with AD and 50 age- and sex-matched controls. The patients met the criteria of probable AD of the National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer,s Disease and Related Disorders Association (NINCDS-ADRDA) and AD of the Diagnostic and Statistical Manual of Mental Disorders 4th edition (DSM-IV). There were 28 females and 22 males in the case and control groups. The mean age of onset of AD was 72.62 years. The average interval between onset and research was 3.85 years. The frequency of ApoEε4 in the AD group was significantly higher than that in the controls (0.13 versus 0.02, p<0.05). The odds ratio for AD in individuals with at least one ApoEε4 allele was 6.0 (95% CI 1.34 to 55.3, p<0.001). The linear trend for AD in proportion to alleles of ApoEε4 was significant (χ2 = 8.3, p = 0.004). The risk of ApoEε4 allele for the late-onset AD patients, males, or those who had received less education was higher than that for the early-onset AD patients, females, or those who had received more education. The sensitivity of the ε4 allele was 24%, the specificity 96%, the positive predictive value 86%, and the negative predictive value 56%. Our results supported that the ApoEε4 allele is related to AD in Taiwan. In addition, sex and education may play important roles in the presence of ApoEε4 allele. The ε4 allele seemed helpful as an adjunct for diagnostic testing of AD. |
本系統中英文摘要資訊取自各篇刊載內容。