查詢結果分析
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頁籤選單縮合
題名 | Insulin Action and Insulin Secretion in Newly Diagnosed Type 2 Diabetic Patients=新診斷第二型糖尿病病人胰島素之作用及分泌 |
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作者 | 曾競鋒; 陳政宏; 蕭璧容; 謝明家; 辛錫璋; | 書刊名 | The Kaohsiung Journal of Medical Sciences |
卷期 | 17:9 2001.09[民90.09] |
頁次 | 頁468-474 |
分類號 | 415.6681 |
關鍵詞 | 第二型糖尿病; 胰島素; Insulin action; Insulin secretion; C-peptide; OGTT; Newly diagnosed type 2 DM; |
語文 | 英文(English) |
中文摘要 | 在本研究中,為了更清楚了解新診斷第二型糖尿病病人的胰島素之作 用及其分泌的情形,我們在十五名新診斷第二型糖尿病病人及十七名健康對照組 中,給予口服葡萄糖的刺激後,測定血清中胰島素及C-peptide的反應。在胰島 素的作用方面,我們發現在新診斷糖尿病病人與正常對照組相較之下有空腹高胰 島素血症(8.4±0.8 vs. 6.0 ±0.5 μIU/ml, p=0.014);高胰島素阻抗(4.33 ±0.2 vs. 1.34±0.1 μIU/ml•mmol/l, p<0.001, HOMA模式);及低的胰島素敏感指數(51.0±0.7 vs. 104.0 ±0.8, p<0.001)。在胰島素的分泌方面,新診斷糖尿病病人胰島素與 C-Peptide曲線下增加的面積 (胰島素26.1 ±1.4 vs. 82.8 ±4.5 μIU/ml•hour, p< 0.001; C-Peptide: 3.9 ±0.2 vs. 11.4±0.6 ng/ml•hour, p< 0.001),胰島素分泌(20.7 ±1.2 vs. 79.1±3.8 IU/mol, p<0.001, HOMA模示)及口服葡萄糖的刺激三十分鐘後 胰島素及葡萄糖增加量的比值(1.14 ±0.1 vs. 13.1 ±0.5 IU/mol, p<0.001) 均較正常 對照組呈現有意義的低。此外,我們亦注意到新診斷第二型糖尿病病人的身體質 量指數(body mass index: 24 ×0.65 kg/m2)與西方國家比較起來相對上較不肥胖。 上述結果顯示在臺灣相對不肥胖的新診斷第二型糖尿病病人,仍有較高的胰島素 阻抗性及較少的胰島素分泌。 |
英文摘要 | To clarify the insulin action and insulin secretion in newly diagnosed type 2 diabetic subjects, we investigated insulin and C-peptide response to an oral glucose tolerance test (OGTT) in 15 newly diagnosed type 2 diabetic patients and 17 healthy subjects. For insulin action, we found fasting hyperinsulinemia (8.4 ?0.8 vs. 6.0 ?0.5μIU/ml, p=0.014), higher insulin resistance by homeostasis model assessment (HOMA) (4.33 ?0.2 vs. 1.34 ?0.1 μIU/ml•mmol/l, p<0.001), and lower insulin sensitivity index (ISI) (51.0 ?0.7 vs. 104.0 ?0.8, p<0.001) in newly diagnosed diabetic patients compared to normal subjects. For insulin secretion, the increments of AUCI (area under curve of insulin) and AUCC-P (area under curve of C-peptide) (increment of AUCI: 26.1 ?1.4 vs. 82.8 ?4.5 μIU/ml•hour, p< 0.001; increment of AUCC-P: 3.9 ?0.2 vs. 11.4 ?0.6 ng/ml•hour, p< 0.001), insulin secretion by HOMA model (20.7 ?1.2 vs. 79.1 ?3.8 IU/mol, p<0.001), and ratio of 30 min increment of fasting insulin to glucose during OGTT (1.14 ?0.1 vs. 13.1 ?0.5 IU/mol, p<0.001) were significantly lower in the newly diagnosed diabetic patients than normal subjects. In addition, body mass index (BMI) in our type 2 diabetes is relatively lower (24 ?0.65 kg/m2) than those in western countries. These findings revealed poor insulin action and decreased insulin secretion in relatively less obese Taiwanese with newly diagnosed type 2 diabetes. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。