查詢結果分析
相關文獻
- Assessment of the Purity of D,L-CB-PAO from Diastereoisomeric Mixtures Using Xrpd Method
- 鎝環丁基丙烯胺肟非鏡像立體異構物合成路徑與影響因子之探討
- 肝癌治療核醫藥物[仦I/[fef3]]Iododeoxyuridine 之合成與配方研究
- Radiosynthesis of 6-[洤F]Fluoro-L-FDOPA for Dopaminergic Function Imaging with PET
- 臨床核醫藥物之最新發展
- Kinetic Studies on the Acid Decomposition of 阷TcO-HMPAO Diastereoisomers
- 鎝同位素及配位化合物在核子醫學上之發展與應用
- 鎝氧環丁基丙烯氨圬非鏡像立體異構物作為局部腦血流腦灌注造影劑之動物實驗評估
- 放射核種的治療應用評論
- 同位素與核醫藥物研發與應用專輯序言
頁籤選單縮合
題名 | Assessment of the Purity of D,L-CB-PAO from Diastereoisomeric Mixtures Using Xrpd Method=以X光粉末燒射法評估非鏡像立體異構物 d,l-CB-PAO 之立體化學純度 |
---|---|
作者 | 蔡長書; | 書刊名 | 慈濟技術學院學報 |
卷期 | 3 2001.08[民90.08] |
頁次 | 頁93-109 |
分類號 | 343.318 |
關鍵詞 | 非鏡像立體異構物; 立體化學純度; 微差掃描卡計; X光粉末燒射; 核醫藥物; Diastereoisomer; Stereochemical purity; Differential scanning calorimetry; DSC; X-ray power diffraction; XRPD; Radiopharmaceutical; |
語文 | 英文(English) |
中文摘要 | 先利用有機合成法製備CB-PAO非鏡像立體異構物,並以多次分步再結晶法有效分離d,l-型、 meso-型及非晶成份之立體異構物,另以熱分析法之微差掃描卡計 (DSC) 進行各成分熔點之測定。本研究嘗試以X光粉末繞射法 (XRPD) 建立一套可用來評估核醫藥物配位子d,l-CB-PAO非鏡像立體異構物之立體化學純度之可行性技術。根據XRPD特性型式,純化之d,l-型及meso-型的繞射峰特性指紋分別為2θ=18.54°,d=4.78 A及2θ=10.87°,d=8.13 A,非晶不純物成分為2θ=18.92°,d=4.67 A。以不同重量比例1:1,2:1及4:1之d,l-與meso-CB-PAO混合物進行同樣測試,發現meso-不純物依50 %、33.3 %、20 %遞減, d,l-型之繞射峰強度由1236.01,2486.6,3545.85呈一線性比例關係遞增。由以上初步結果顯示,配合DSC以XRPD法作為d,l-CB-PAO非鏡像立體異構物之立體化學純度評估,在定性與定量方面不失為一可行的方法。 |
英文摘要 | The diastereoisomers of CB-PAO were synthesized and d,l-CB-PAO, meso-CB-PAO and amorphous CB-PAO fractions were separated by repeated fractional recrystallization. Melting point measurement by using DSC was carried out very carefully. Attempt was made to use x-ray powder diffraction pattern method to evaluate the stereochemical purity of d,l-CB-PAO ligand. According to their characteristic of XRPD patterns, pure d,l-CB-PAO and meso-CB-PAO with fingerprints of 2 = 18.54 ; d = 4.78 A and 2 = 10.87 ; d = 8.13 A , respectively. For amorphous fraction it is 2 = 18.92 ; d = 4.67 A. A series of mixture with the fixed ratios of 1:1, 2:1 and 4:1 with respect to d,l-isomers and meso- isomers were prepared and their XRPD pattern were recorded. It was observed from the XRPD patterns that the impurity of meso-CB-PAO decreased by 50 %, 33.3 %, and 20 %, respectively; and the peak intensities, for the d,l-CB-PAO increased linearly as observed with the figures 1236.06, 2486.6 and 3545.85. It seemed that XRPD method is qualitatively and quantitatively feasible for the assessment of the purity of d,l-CB-PAO from diastereoisomeric mixtures. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。