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題名 | Two Clinical Variants of Chinese-Herb Nephropathy: Case Reports and Review of the Literature=中藥腎病變之兩種不同臨床表現型態:兩例個案報告及文獻回顧 |
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作者 | 楊松昇; 朱柏齡; 林美香; 陳安; 林裕峰; | 書刊名 | 醫學研究 |
卷期 | 21:4 2001.08[民90.08] |
頁次 | 頁217-224 |
分類號 | 415.74 |
關鍵詞 | 貧血; 范氏徵狀群; 中藥腎病變; Anemia; Aristolochic acids; Chinese herb nephropathy; Fanconi syndrome; Renal failure; |
語文 | 英文(English) |
英文摘要 | Chinese herb nephropathy (CHN) has been reported in recent years after consuming Chinese herb remedies. Aristolochic acids (AAs) were claimed to be causative agents in CHN. We described two patients with Chinese herb nephropathy, one presented with subacute and irreversible renal failure and severe anemia. Urothelial carcinoma developed after she received regular hemodialysis therapy due to irreversible renal failure. The other manifested with Fanconi syndrome characterized with hyperchloremic metabolic acidosis, impaired proximal bicarbonate reclamation, phosphaturia, glucosuria, uricosuria, aminoaciduria, and proteinuria. The renal biopsy revealed typical findings of CHN with diffuse renal tubular atrophic change, mild glomerular ischemic collapse and mild diffuse interstitial fibrosis. AAs were detected in the remedies these two patients consumed. We conclude that Chinese herb nephropathy has two clinical variants. One is subacute renal failure with severe anemia and the other is Fanconi syndrome. Chinese herbs of Aristolocia species containing AAs should not be used to avoid the development of CHN. |
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