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題名 | 靜脈注射含碘對比劑之不良反應:一家醫學中心之經驗=Adverse Reactions to Intravenous Administration Iodinated Contrast Media: Experience in a Medical Center |
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作者姓名(中文) | 楊慧珍; 李潤川; 鄧木火; 張政彥; | 書刊名 | 中華放射線醫學雜誌 |
卷期 | 26:1 2001.02[民90.02] |
頁次 | 頁17-21 |
分類號 | 418.346 |
關鍵詞 | 放射線檢查; 對比劑; 不良反應; X-ray examination; Contrast medium; Adverse reaction; |
語文 | 中文(Chinese) |
中文摘要 | 背景:含碘對比劑的藥物不良反應為日常放射線檢查常遭遇的問題,放射線各項使用對比劑的檢查中,以注射含碘對比劑導致不良反應的比例最高。本研究目的在收集紀錄靜脈注射含碘對比劑的藥物不良反應(adverse reactions)之輕重程度和型態,並分析其與對比劑種類之相關性。方法:含碘對比劑可分為離子性及非離子性,本文研究一家醫學中心18個月日常工作的時間中,對接受靜脈內注射含碘對比劑(包括腎臟腎盂攝影﹝lVP﹞及電腦斷層攝影)導致不良反應之病患作詳細之記錄與評估。結果:於上述之研究期間,總計有28364人接受靜脈內注射對比劑,發生不良反應者共有495人,發生例約為1.745%。注射非離子性對比劑者有8104人,發生不良反應者28人,比例為0.346%,注射離子性對比劑者有20260人,發生不良反應者467人,比例為2.305%,注射非離子性對比劑發生不良反應之機會較低是有統計學意義的(p<0.001)。針對不良反應種類、比例及嚴重程度作分析,可見其中以輕度反應之皮膚症狀(局限性蕁麻疹)的表現最為罕見(離子性對比劑引起者1.175%,非離子性對比劑引起者0.197%),其次為嘔吐、噁心,症狀嚴重至需要急救小組作緊急處理的有6人(皆為離子性引起,比例為0.030%),佔受檢總人數28364人之0.021%。結論:本研究結果將有助於放射線從業人員能更熟悉靜脈內注射對比劑所發生之不良反應,機警地注意到症狀的發生,給予迅速而適當的處理,可以盡量減少副作用及併發症發生,避免受檢病患遭受更嚴重之傷害。 |
英文摘要 | Background: Adverse reactions to intravenous injection of iodinated contrast media are commonly encountered in routine radiological practice. The purpose of this study was to investigate the adverse reactions to intravenous injection of iodinated contrast media. The correlation between contrast media type and the severity and risk of an adverse reaction was analyzed. Materials and Methods: Cases of intravenous contrast media induced reactions during intravenous pyelography (IVP) and computed tomography (CT) in a medical center over an 18 month period were collected. The type, severity and risk of adverse reactions were analyzed. Results: Over the study period, intravenous injection of iodinated contrast media took place in 28364 patients, with adverse reactions occurring in 495. The risk of an adverse reactions was around 1.745%. The risk of an adverse reaction to ionic contrast media was 2.035% (467/20260)and to non-ionic contrast media was 0.346% (28/8076).The data show that the risk of an adverse reactions to non-ionic contrast media is significantly lower than for ionic contrast media (p<0.001). Cutaneous symptoms such as urticaria are the most commonly seen reactions, followed by nausea and vomiting. In the series, there were six cases (0.021%) of shock requiring cardiopulmonary resuscitation (CPR), but no fatalities. Conclusions: This study highlights the most common symptoms seen in adverse reactions to intravenous contrast media, aiding early diagnosis. Appropriate management and the use of non-ionic contrast can minimize the risk of severe complications. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。