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題 名 | HLA-DQA1 Genotyping in Patients with Rheumatoid Arthritis in Taiwan=臺灣地區類風濕性關節炎病人之HLA-DQA1基因型 |
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作 者 | 顏正賢; 陳忠仁; 蔡文展; 歐燦騰; 林嘉慧; 林世昌; 劉宏文; | 書刊名 | The Kaohsiung Journal of Medical Sciences |
卷 期 | 17:4 2001.04[民90.04] |
頁 次 | 頁183-189 |
分類號 | 415.695 |
關鍵詞 | 臺灣地區; 類風濕性關節炎; HLA-DQA1基因型; HLA-DQ; HLA-DR; Genotype; Rheumatoid arthritis; SSP/PCR; |
語 文 | 英文(English) |
中文摘要 | 為了探討HLA-DQA1基因及其和HLA-DRB1間的交互作用,在台灣 地區類風濕性關節炎病人的致病機轉中所扮演的角色。我們選擇了71個RA病 人和108個正常人,利用SSP-PCR方法測定其HLA-DQA1基因型。其中,同時 有55個RA病人和101個正常人利用PCR╱SSOP方法檢測其HLA-DRB1,而 HLA-DR4的亞型則是利用選殖定序法測定。類風濕性關節炎病人具有 HLA-DQA1*0301的機會比正常人顯著減少,而具有HLA-DQA1*0302或 DQA1*0303的機會則比正常人顯著增高。而且,DQA1*0301、*0302 、*0303 和RA間的關係與HLA-DR4、DRB1 *0405無關。再者,HLA-DR4和 HLA-DQA1*0302或DQA1*0303同時出現時更可加強它們和RA間的關係。吾 人同時發現HLA-DQA1*0303陽性的RA病人比陰性者發生骨骼糜爛和出現類風 濕因子的機會顯著增加。HLA-DQA1*0302和DQA1*0303是發生類風濕性關節 炎的危險因子而DQA1*0301則是保護因子。同時具有HLA-DR4和DQA1*0302 或DQA1*0303對該病的發生有加成作用。而且,HLA-DQA1*0303和骨骼糜爛 以及類風濕因子的出現有關。 |
英文摘要 | To investigate the role of HLA-DQA1 genotypes and their interaction with HLA-DRB1 in the pathogenesis of rheumatoid arthritis (RA) in Taiwan, HLA-DQA1 was determined in 71 patients with RA and 108 healthy controls by SSP-PCR method. HLA-DRB1 and HLA-DQA1 were simultaneously detected in 55 RA patients and 101 healthy controls. PCR/SSOP method was used to determine the HLA-DRB1 genotypes, and the subtypes of HLA-DR4 were determined by cloning and sequencing. The phenotypic frequency of HLA-DQA1*0301 was significantly lower in RA than in controls, and, in contrast, the HLA-DQA1*0302 and DQA1*0303 were significantly higher in RA than in controls. The associations of DQA1*0301, *0302, and *0303 with RA were independent of DR4 and DRB1*0405. Moreover, the interactions between HLA-DR4 and HLA-DQA1*0302 or DQA1*0303 could enhance the development of RA. We also found that the prevalence of bone erosion and seropositivity of rheumatoid factor (RF) were significantly higher in HLA-DQA1*0303 positive RA patients than in healthy controls. HLA-DQA1*0302 and DQA1*0303 are the risk factors for susceptibility to RA, while HLA-DQA1*0301 is a protective factor. A synergistic effect for the susceptibility to RA can be found between HLA-DR4 and HLA-DQA1*0302 or DQA1*0303. We also found that the HLA-DQA1*0303 was related to bone erosion and seropositivity of RF in RA patients. |
本系統中英文摘要資訊取自各篇刊載內容。