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題名 | 會厭軟骨之惡性纖維組織細胞瘤併鱗狀上皮細胞癌--病例報告=Malignant Fibrous Histiocytoma Associated with Squamous Cell Carcinoma in Epiglottis--Case Report |
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作者 | 顧哲銘; 朱敬中; 賴義雄; | 書刊名 | 中華民國耳鼻喉科醫學雜誌 |
卷期 | 36:3 民90.05-06 |
頁次 | 頁177-180 |
分類號 | 416.894 |
關鍵詞 | 惡性纖維組織細胞瘤; 鱗狀上皮細胞癌; 會厭軟骨; Malignant fibrous histiocytoma; Squamous cell carcinoma; Epiglottis; |
語文 | 中文(Chinese) |
中文摘要 | 喉部惡性纖維組織細胞瘤,是極為罕見的腫瘤,其具有侵犯性、高復發性及高轉 移性。這種腫瘤細胞類似組織球細胞,在特定情況下會有纖維母細胞的功能。男女發生比率 約為 3:1,男性易發生在 50-60 歲, 女性則易發生在 30-40 歲,而發生部位男女亦有別 ,男性多在聲門區,女性則多在下聲門區,治療方法主要以廣泛性切除為主,術後放射線治 療及化學治療僅扮演輔助性的角色。本科提出一 49 歲男性病例,除了惡性纖維組織細胞瘤 長在會厭軟骨外,且在其周圍發現有鱗狀上皮細胞癌併生,檢索現有之文獻未曾有類似報告 。 |
英文摘要 | Malignant fibrous histiocytoma (MFH) is rare in the larynx. The tumor is aggressive as it tends to both recur and metastasize to distant organs. It is a tumor consisting mainly of histiocyte-like cells, giant cells and spindle cells, often arranged in a storiform pattern. MHF of the larynx appears to be more common in males than in females, with females typically presenting in the 4th decade and males in the 6th decade. The disease is more commonly subglottic in females while in males it is often glottic. The treatment of choice is wide excision with or without adjuvant radiotherapy and chemotherapy. A case of epiglottic MHF associated with SCC in a 49-year-old male is described. The patient underwent wide excision with clear margins but refused further radiotherapy. The patient is alive and free of disease after one year of follow-up. MHF associated with SCC of the epiglottis is quite unique and its histologic diagnosis is difficult to establish. We recommend a detailed physical examination followed by wide ranging and adequate biopsies for the diagnosis of this disease. |
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