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題名 | Human Progesterone Receptor Shows Differential Sensitivity to Carboxyl Group Modifying Agents When Bound to Agonist and Antagonist Ligands=當結合催動劑和拮抗劑之人類黃體激素接受體對羧基修飾劑顯示不同的感受性 |
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作者姓名(中文) | 吳啟銘; 劉自嘉; 黃菊春; 黃燦龍; 潘榮隆; | 書刊名 | 長庚醫學 |
卷期 | 24:3 2001.03[民90.03] |
頁次 | 頁151-158 |
分類號 | 415.121 |
關鍵詞 | 黃體激素接受體; 催動劑; 拮抗劑; 化學修飾; 黃體激素; Progesterone receptor; Agonist; Antagonist; Chemical modification; Progesterone; |
語文 | 英文(English) |
英文摘要 | Background: Modulation of human uterine progesterone receptor (PR) in relation to its binding to synthetic steroids with known agonist (R5020) and antagonist (triamcinolone acetonide, T.A.) properties was studied in the presence of the specific carboxyl group modifiers, N,N'-dicyclohexylcarbodiimide (DCCD) and 1-ethyl-3-carbodiimide hydrochloride (EDC). Methods: Uterine cytosol was treated with DCCD or EDC. The amounts of total bound were detected using the steroid binding measurements. The formation and transformation of progesterone-receptor complexes (PRc) were analyzed using sedimentation rate analysis. Results: Our studies show that the modification of the COOH group differentially influences the properties of mammalian PR binding with either R5020 or T.A. DCCD and EDC affect the steroid binding of PR by decreasing the binding sites, not by the changing the affinity. Conclusion: Our studies indicate the importance of the carboxyl group in steroid binding by PR. This implies that both aspartic acid and glutamic acid residues, which have the carboxyl group, may play an important role when PR binds with steroid ligands.(Chang Gung Med 2001;24:151-8) |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。