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題名 | Prurigo Pigmentosa--A Report of Four Cases=色素性癢疹--四病例報告 |
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作者 | 蕭嘉蓉; 李玉雲; 許漢銘; | 書刊名 | 中華皮膚科醫學雜誌 |
卷期 | 18:4 2000.12[民89.12] |
頁次 | 頁311-317 |
分類號 | 415.7 |
關鍵詞 | 色素性癢疹; Prurigo pigmentosa; Intraepidermal vesicle; Reticulate degeneration; Nuclear dust; Ketones; |
語文 | 英文(English) |
中文摘要 | 色素性癢疹〈PP〉是一種少見的網狀色素性搔癢病症。文獻上已有兩個臺灣人病例。吾人報告四個新病例,包括一些新的組織病理變化。四例的臨床表現及對minocycline的治療反應皆相當典型,病理上可見PP特徵性的變化,包括基底層細胞液化變性,海綿樣水腫,表皮細胞壞死,淋巴球表皮浸潤及苔蘚樣淋巴球,或偶有嗜依紅球浸潤。但有3例可見2種以前未曾報告過的變化;一例其臨床上並無明顯水泡,但切片下可見因表皮大片融合樣壞死及網狀汽球狀退化而形成之表皮內水泡,另二例之表皮內出現淋巴球細胞核碎片。 |
英文摘要 | Prurigo pigmentosa (PP) is an uncommon skin disease characterized by a pruritic reticulated erythematous popular eruption that leaves a mottled hyperpigmentation after resolution. To date, only 2 cases were reported from Taiwan. In this report, we describe four cases of PP with typical clinical features and dramatic therapeutic response to minocycline. Histopathologically, characteristic findings of PP, namely vacuolar alteration of basal cells, spongiosis, necrosis of keratinocytes, exocytosis of lymphocytes and a patchy lichenoid or lichenoid predominantly lymphocytic and occasionally eosinophilic infiltration were observed. However, two unusual new findings were noted in 3 cases; one case showed extensive necrosis of keratinocytes as well as reticulate degeneration resulting in intraepidermal vesicles, the other two cases displayed lymphocytic nuclear dust in the epidermis. |
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