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題名 | Alterations in Ca[fec7] Signaling, and c-fos and nur77 Expression are Associated with Sodium Butyrate-Induced Differentiation of C6 Glioma Cell |
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作者姓名(外文) | Jang,Te-hsuan; Sun,Synthia H.; | 書刊名 | 中國生理學雜誌 |
卷期 | 43:4 2000.12[民89.12] |
頁次 | 頁149-158 |
分類號 | 418.31 |
關鍵詞 | 丁酸鈉; ATP; Ca[fec7] signaling; Ca[fec7] release; C6 glioma cells; c-fos; c-myc; Nur77; Sodium butyrate; Thapsgargin; |
語文 | 英文(English) |
英文摘要 | Sodium butyrate is well known in stimulating growth and differentiation of cancer cells. In the present study, butyrate treatment caused decreases in thymidine incorporation in the early passages (45-60) of C6 glioma cells. In addition, butyrate also caused decreases in inositol incorporation and transient ATP. stimulated Ca^(2+) mobilization suggesting that butyrate altered general mechanisms of Ca^(2+) signaling in these cells. To gain direct insight into the crosstalk between sodium butyrate and Ca^(2+) signaling in transcriptional regulation, we investigated the induction of the Ca^(2+). sensitive immediate early genes (IEGs), c-fos, nur77 and c-myc. Sodium butyrate per se enhanced the expression of c-fos mRNA, and the enhanced levels were maintained for 24h, but over the same time period, the initially increased levels of nur77 expression tailed off, while c-myc expression was slightly reduced. Increasing intracellular Ca^(2+) concentration ([Ca^(2+)]i) by thapsgargin and A23187 induced the expression of both c-fos and nur77 mRNA expression, and synergistic effects were observed when cells were incubated with sodium butyrate plus thapsgargin and A23187. However, removal of both extracellular Ca^(2+) by EGTA, or intracellular free Ca^(2+) with BAPTA did not affect the sodium butyrate-induced c-fos and nur77 mRNA. These results suggest that although sodium butyrate altered Ca^(2+) signaling which is an important regulatory mechanism for c-fos and nur77 expression, nevertheless the sodium butyrate. induced c-fos and nur77 expression may be not in fact mediated through Ca2 signaling. |
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