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頁籤選單縮合
題 名 | Immunopathogenesis of Viral Hepatitis B and C=B型與C型肝炎的免疫致病機制 |
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作 者 | 蔡順隆; | 書刊名 | 長庚醫學 |
卷 期 | 22:2 1999.06[民88.06] |
頁 次 | 頁159-170 |
分類號 | 415.5332 |
關鍵詞 | 毒殺性T淋巴球; 慢性感染; 輔助型T淋巴球; B型肝炎病毒; C型肝炎病毒; 組織相容抗原限制; Cytotoxic T lymphocyte; Chronicity; Helper T lymphocyte; Hepatitis B virus; Hepatitis C virus; MHC-restriction; |
語 文 | 英文(English) |
中文摘要 | 許多證據顯示,免疫機制對B型(HBV)與C型(HCV)肝炎病毒的致病扮演重要的角度 。 對病毒抗原的反應,組織相容抗原第一型限制的 CD8+T 細胞反應與第二型限制的 CD4+T 細胞反應,兩者都是可能引發 HBV 與 HCV 感染肝細胞之傷害的機制。 對 HBV 核心抗原的 CD4+T 細胞增殖反應,其刺激指數與肝炎活性相關。此反應在成人與小孩病患的研究結果相 類似,而且在急性 B 肝炎復原者反應特別強烈。在慢性 B 型肝炎者則較弱。 在 C 型肝炎 患者的研究也有相同發現,急性 C 型肝炎有恢復者,其 CD4+T 細胞對病毒抗原有強烈的反 應,比演變成慢性感染者有明顯差異。在組織相容抗原第一型限制的 CD8+T 細胞對 HBV 的 核心抗原、表面抗原,及聚合酉每的標的細胞皆會產生毒殺性的反應。 相同地,對 HCV 抗 原的標的細胞也有多重的而且多發性毒殺性 CD8+T 細胞反應,而與 C 型肝炎病毒包括野生 型與變異種共存於感染個體內。 B 型與 C 型肝炎病毒引發慢性感染的機制則仍待探討。 |
英文摘要 | Considerable evidence suggests that immune mechanisms are involved in the pathogenesis of both hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. Both class Ⅰ -restricted CD8+T cell and class Ⅱ -restricted CD4+T cell responses to viral antigens are important mechanisms that may be responsible for the hepatocyte damage in hepatitis B and C. CD4+T cell proliferative responses to hepatitis B core antigen (HBcAg) in terms of stimulation index are correlated with hepatitis activity. These responses can be demonstrated in both adult and pediatric patients, and are more vigorous in patients with acute self-limited hepatitis B than in patients with chronic hepatitis B. Patients with hepatitis C also have a significant CD4+T cell response to HCV antigens. These responses are also more vigorous in acute hepatitis C patients who recover than in patients who evolve to chronic hepatitis. In terms of major histocompatibility complexes (MHC) class Ⅰ -restricted, CD8+ cytotoxic T lymphocyte (CTL) response, antigenic peptides derived from HBcAg, hepatitis B surface antigen (HBsAg), and polymerase have been demonstrated to be the targets for CTL recognition in hepatitis B patients. Multiple CTL epitopes within HBsAg, HBcAg and polymerase can be detected by sensitizing target cells with synthetic peptides. Likewise, multispecific, HCV-specific CTL responses can coexist with an extensive quasispecies of viral variants. The mechanisms of viral persistence in both hepatitis B and C remain to be clarified. |
本系統中英文摘要資訊取自各篇刊載內容。