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題名 | 慢釋型Carbamazepine與傳統型Carbamazepine對酒精戒斷症狀之療效:初報=Efficacy of Controlled-release Carbamazepine Versus Conventional Carbamazepine on Alcohol Withdrawal Syndrome: Preliminary Study |
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作者姓名(中文) | 汪振洋; 江淑娟; 郭錫卿; 張達人; 陳朝灶; | 書刊名 | 臺灣精神醫學 |
卷期 | 14:3 2000.09[民89.09] |
頁次 | 頁68-75 |
分類號 | 418.21 |
關鍵詞 | 酒精戒斷; 藥物治療; 慢釋型carbamazepine; 傳統型carbamazepine; Alcohol withdrawal; Pharmacotherapy; Controlled-release carbamazepine; Carbamazepine; |
語文 | 中文(Chinese) |
中文摘要 | 目的:比較兩種不同的carbamazepine(CBZ)劑型,對酒精戒斷的療效及副作用 。方法:於1997年6月至1999年1月間,因酒精戒斷症狀住院之病患,其戒斷症狀達CIWA≧ 19分以上者,以開放式研究方法,隨機分為二組,一組投與慢釋型CBZ(CBZ-CR)(實驗組 ),另一組投與傳統型CBZ(CBZ)(控制組), 以CIWA-A scale 評估臨床戒斷症狀改善程 度及副作用產生情形。統計分析比較兩組個案的基本資料、酒癮病史、臨床戒斷症狀、服 藥後症狀改善情形、藥物使用劑量、血中濃度、副作用及病患主觀感受等資料。結果:17 名個案符合本研究需以藥物治療之戒斷嚴重程度,其中實驗組11人,控制組6人。兩組個案 在基本資料、酒癮病史、戒斷症狀嚴重度、藥物上所用之劑量、藥物濃度無差異。而服藥 後症狀改善速率,即CIWA-A分數降至10分所需之小時數,平均值分別為10小時(CBZ-CR組) 及14小時(CBZ組),在統計上亦無差異。除有一個案在CBZ-CR組產生皮疹外,餘皆無嚴重 之副作用或白血球減少之情形,副作用比較上兩組無差異。CBZ-CR組個案主觀上較能接受。 結論:慢釋型carbamazepine與傳統型carbamazepine在治療酒精戒斷病患症狀方面,沒有 顯示療效上的差異,CBZ-CR組病患之主觀接受度較佳。可在日後治療酒精戒斷病患上,多 一治療藥物的選擇。 |
英文摘要 | Objective: This research implemented a comparative study for two kinds of carbamazepine (CBZ) with different pharmacodynamics, analyzing and discussing the different of the effects of controlled-release and conventional variants as reflected in treatment course for hospitalized patients with alcohol withdrawal syndrome. Methods: Patients hospitalized with alcohol with drawal syndrome (CIWA -A scales≧19)were included in this open-trial study. The case collection took place from Nov. 1997 to Apr, 1999, with patients randomly divided into two groups. The frist group was selected as the study group treated with controled-release carbamazepine (CBZ-CR) with the second group selected as the control group treated with the conventional analog. After evaluation of clinical-symptom improvement utilizing the CIWA-A scale, basic data, alcholism history, alcohol- withdrawal-syndrome improvement after treatment, medication dosage and drug blood level were collected and subjected to various statistical analyses. Results: Seventeen cases were deemed appropriate for drug treatment according to the severity level called for in this research, with 11 cases in the study group and six in the control group. Staticstical analysis revealed no significant differences comparing basic data, alcoholism history and severity of alcohol withdrawal syndrome for these two groups, with no significant difference for medication dosage and drug blood level. The controlled-release drug was more acceptable to patients. Conclusion: This research demonstrates that the controlled-release and conventional carbamazepine variants produce no differences for drug effects for patients with alcohol withdrawal syndrome, however, controlled-release carbamazepine was more acceptable to patients. This indicates that there is one more drug choice available for patients suffering from alcohol withdrawal syndrome. {Full Text in Chinese). |
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