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題名 | 同半胱胺酸和血管疾病的關係=The Relationship between Homocysteine and Vascular Diseases |
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作 者 | 林宗坤; 蘇慕寰; 林利珍; | 書刊名 | 國防醫學 |
卷期 | 31:6 2000.12[民89.12] |
頁次 | 頁706-715 |
分類號 | 416.263 |
關鍵詞 | 高同半胱胺酸血症; 動脈粥樣硬化; Hyperhomocysteinemia; Atherosclerosis; |
語文 | 中文(Chinese) |
中文摘要 | 近年來,流行病學資料顯示血液中同半胱胺酸濃度較高的人,死亡率比濃度正常的人高,尤其是在末期腎病變(ESRD)和第二類型的糖尿病病人身上可以發現血液中同半胱胺酸濃度升高的現象。回顧過去與現在關於同半胱胺酸的研究報告,大多數都已經證實了血中同半胱胺酸濃度升高時有造成動脈粥樣硬化的可能。目前臨床上仍然缺乏長期的大型人體實驗,證明動脈粥樣硬化病人血液中同半胱胺酸濃度升高時,以維生素營養療法降低血液中同半胱胺酸濃度是否能改善動脈粥樣硬化,進而降低血管疾病病人的死亡率。本篇文章主要在探討造成心、腦血管疾病的獨立危險因子-同半胱胺酸(homocysteine, Hcy)在人體中的生化代謝、影響因素、致病機轉和治療方法等。 |
英文摘要 | Most recently, epidemiological studies have shown an increase in mortality in patients with elevated homocysteine concentrations compaired with healthy volunteers. In addition, a positive correlation exists between high homocysteine concentrations and certain disease states, such as end-stage renal disease (ESRD) and type 2 diabetes. Retrospective and prospective studies demonstrate a positive correlation between high homocysteine concentration and atherosclerosis. Although no long-term clinical trials have assessed the risk of atherosclerosis when patients with elevated homocysteine concentrations are treated for vitamin supplementation, treatment may be beneficial in reducing homocysteine concentration and decreasing mortality in atherosclerosis patient. This report will discuss the role of homocysteine as a risk factor in the pathogenesis of atherosclerosis and to introduce metabolism, affecting factors, mechanism and treatment of homocysteine in human. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。