查詢結果分析
來源資料
相關文獻
- 抗風濕中藥對細胞激素刺激類風濕滑膜細胞凋亡(Apoptosis)之影響
- Fas and CD45RO Antigen Expression on Peripheral Blood Mononuclear Cells in Patients with Ankylosing Spondylitis: A Comparison with Autoimmune Diseases
- 玉屏風散單味藥及不同組合方劑在體外試驗對單核細胞釋放第2介白質及前列腺素E[feaf]之影響
- 臺灣市售易誤用、混用中藥品之調查
- 中藥對口腔病原菌及牙周病治療效果之評估
- 呼吸道感染之中藥療法
- 由中藥草中分離能提升輻射治療效果之輻射增敏劑(2)
- 中藥材微量有機氯農藥之超臨界流體檢驗方法之研究
- 中藥單味濃縮製劑品管規格之制定研究
- 中藥製劑基準方重金屬限量規格制訂之研究
頁籤選單縮合
題 名 | 抗風濕中藥對細胞激素刺激類風濕滑膜細胞凋亡(Apoptosis)之影響=The Effect of Anti-Rheumatic Herbs on Cytokine-Induced Apoptosis of Rheumatoid Synovium |
---|---|
作 者 | 周昌德; | 書刊名 | 中醫藥年報 |
卷 期 | 17:1 1999.05[民88.05] |
頁 次 | 頁595-611 |
分類號 | 413.3 |
關鍵詞 | 中藥; 滑膜細胞; 風濕免疫病; Fas抗原; Herb; Synovial fibroblasts; Rheumatic-immune disease; Fas antigen; |
語 文 | 中文(Chinese) |
中文摘要 | 類風濕關節炎(RA)是一自體免疫病,近年來研究已瞭解許多不同組織細胞包括滑 膜、 關節液中之類纖維細胞及中性白血球易出現細胞凋亡之現象 (Apoptosis) 而細胞凋亡 可能是自體免疫病發病之重要機轉,而 Fas 抗原在細胞表現增加或 DNA 斷裂增加可反映出 細胞是否凋亡。而中藥治療 RA 種類相當繁多。本研究使用先前已證實具有抗風濕免疫作用 中藥,包括雷公藤、蕙以仁湯、麻杏蕙甘湯與西藥 Dexamethason 及在體外與從 RA 分離之 類纖維細胞 (在細胞激素刺激下 ), 以 Flowcytometry 去測定 Fas 抗原表現。 另以 Tunnel 法去瞭解細胞核 DNA, 另外比較 RA 滑膜細胞及 OA( 退化性關節炎 ) Fas 表現之 差異性。結果顯示雷公藤及 Dexamethason 可明顯增加細胞之凋亡,而其中中藥包括蕙以仁 湯、葛根湯、桂枝芍藥知母湯、芍藥甘草湯、麻杏蕙甘湯等卻無明顯作用。臨床上自體免疫 病如 RA 等,使用雷公藤及類固醇有明顯之療效、其可能之機轉為經由增加不正常、發炎或 免疫細胞之細胞凋亡所導致。 |
英文摘要 | Rheumatoid arthritis(RA) is an autoimmune disease. Recent studies have been demonstrated that Fas antigen and apoptosis were significantly increased in synovial fluid cells and synovial fibroblasts. The apoptosis of many activated inflammatory or immune cells is an important mechanism to protect patient from autoimmune and rheumatic disease. Many traditional herbs have been used to treat RA or other inflammatory joint disease. In this study, herb formulas including T2 (ethanol extraction of roots of TWF) , Yi-Yin-Zen-Tang(YYZT) , Ma-Sin-Yi-Gan-Tan(MSYGT), Ger-Gen Tang(GGT), Gue-Zi-Tsou-Zi-Mu-Tang(GTZMT) were extracted with ethanol and dried and dissolved in DMSO solution. Dexamethasone was used as control. Cytokines including TNF (and TGF (were used as stimulants. Different concentrations of herb formulas were incubated with RA synovial fibroblasts and cytokines for 2 days. Fas antigen before herb and after herb treatment was measured with Flowcytometry. The results showed TNF (can significantly increase synovial fibroblast Fas antigen expression. In contrast, TGF (decrease the Fas expression. All herb including T2, YYZT, GTZMT, after 2 days culture with synovial fibroblasts, can downregulate the Fas antigen expression on fibroblasts. In contrast, dexmethacin can upregulate the Fas antigen expression. The beneficial effect of dexamethacin to treat RA probably mediated through the mechanism of apoptosis (when Fas overexpressed) of those activated cells. However, all the traditional herb formulas did not accelerate the apoptosis of those activated synovial fibroblast. |
本系統中英文摘要資訊取自各篇刊載內容。