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題名 | 非侵入式動脈血管黏彈特性之檢驗=Non-Invasive Diagnosis of Arterial Viscoelasticity |
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作者姓名(中文) | 邵耀華; | 書刊名 | 國立臺灣大學工程學刊 |
卷期 | 79 2000.06[民89.06] |
頁次 | 頁1-10 |
分類號 | 415.384 |
關鍵詞 | 超音波; 週邊動脈血管; 機械特性; 黏彈性質; Ultrasound; Peripheral artery; Mechanical properties; Viscoelasticity; Hysteresis; |
語文 | 中文(Chinese) |
中文摘要 | 週邊動脈血管材質異常的改變往往可以視為粥狀硬化或血液循環病變 初現的指標。由於血管複合組織特性,血管的彈性會因血壓大小而改變,管徑 在血壓收縮與舒張期的反應不同,形成非線性負載曲線,而在血管受力變形過 程所消散耗損的能量百分比 (EDR) 有重要的生理意義。本研究發展一非侵入式 血管材質特性量測系統,利用高頻率超音波線性探頭 (10MHz) 配合觸診壓力 計,藉由獨特的同步硬體設計與影像處理,可以在超音波組織影像的動態監控 之下,同步記錄血管的變形與相同位置血壓的脈動,因此可以建立血管壁應力 與應變的變化歷程,進而對於動脈血管的組織 (血管硬度、順應性、黏彈特性) 提供一種簡便的非破壞性檢測。 本研究觀察10位 (22 �b 1歲) 年輕人平躺時之頸動脈 (CCA)、腳背動脈 (DPA)、 橈動脈 (RA)、及手臂動脈 (BA) 的血管機械特性。在正常生理狀態下,CCA 的平均管徑為6.74 �b 0.86mm,血管脈動量比其他週邊血管大很多 (12.2 �b 1.2%), 彈性模數 (Ep, Elastic modulus) 約為 0.44 �e 106dyne/cm2,黏彈能量耗損EDR 約7.2%。BA、RA及DPA之平均管徑分別為3.91mm、2.22mm及2.12mm。血管 脈動應變量則分別為4.60%、4.25% 及8.91%,Ep分別為1.39、1.45及0.90 �e 106 dyne/cm2。相對應之血管能量耗損EDR分別為6.34%、6.15% 及5.60%。實驗結 果顯示正常年輕人的腳背動脈比其他週邊血管軟且有較大的脈動量。 |
英文摘要 | Abnormal changes of mechanical properties in peripheral arteries are often considered as the early indicator of atherosclerosis or circulatory diseases. Due to the complexity of vascular wall layers, the elastic module of blood vessel varies with the blood pressure, and the vessel diameter reacts differently in systolic and diastolic phases, which results in a nonlinear loading and unloading stress-strain curve. The energy dissipated in arterial vessel during cardiac cycle is very important physiologically. We developed a noninvasive technique to assess the mechanical properties and viscoelasticity of peripheral arteries. The pressure-strain elastic modulus (Ep) and the viscoelastic properties (energy dissipation ratio, EDR) of the common carotid artery (CCA), brachial artery (BA), radial artery (RA) and dorsalis pedis artery (DPA) were determined by means of palpating pressure and diameter distension waveforms extracted from high-resolution ultrasonography. The methodology was validated in vitro using an elastic tube phantom as well as in vivo. In vivo study in 10 healthy volunteers showed that their pressure-diameter curves were nonlinear, with an inflection at about 85 ~ 90mmHg, and routed clockwise with slight hysteresis. The CCA (N = 5) had a mean diameter of 6.74mm and the pulsatile diameter distension was 12.2%. The Ep calculated at the CCA was 0.44 �e 106 dyne/cm2 with an EDR of 7.2%. The BA, RA, and DPA (N = 10) had mean diameters of 3.91mm, 2.22mm, and 2.12mm; arterial strains of 4.60%, 4.25%, and 8.91%; mean Ep of 1.39, 1.45, 0.90 �e 106 dyne/cm2; and mean EDRs of 6.34%, 6.15% and 5.60% respectively. In young subjects, their DPA have higher distensibility than the other peripheral arteries. |
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