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題名 | The Effects of Glurenorm on Plasma Glucose and Lipids in Patients with Type 2 Diabetes Mellitus=Glurenorm對第2型糖尿病人的血糖及血脂肪之作用 |
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作者 | 周碩麒; 陳光文; 黃朝俊; 林款帶; 黃兆山; 林仁德; Chou, Shuo-chi; Chen, Kwang-wen; Huang, Chao-chun; Lin, Koan-day; Hwang, Jawl-shan; Lin, Jen-der; |
期刊 | 長庚醫學 |
出版日期 | 20000800 |
卷期 | 23:8 2000.08[民89.08] |
頁次 | 頁480-484 |
分類號 | 415.6681 |
語文 | eng |
關鍵詞 | 糖尿病; 高血脂症; Diabetes mellitus; Glurenorm; Hyperlipidemia; |
英文摘要 | BACKGROUND: The effects of sulfonylureas on plasma glucose, lipids, and macrovascular complications are of interest. This study was designed to investigate the effects of glurenorm on plasma glucose and lipids in patients with type 2 diabetes mellitus. METHODS: Nineteen patients, 15 men and 4 women, with an age range of 38-69 years, and with type 2 diabetes mellitus, were studied. Plasma glucose, glycated hemoglobin, and lipids were compared before and 3 months after glurenorm treatment. RESULTS: Fasting and postprandial plasma glucose, and HbA1c significantly improved after 3 months of glurenorm treatment. The mean (�SD) triglyceride level of 10 patients with mild to moderate hypertriglyceridemia decreased from 279 & #0;66 to 219 & #0;100 mg/dl (p=0.054). The total cholesterol, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) of 14 hypercholesterolemic patients did not change significantly. Their mean body weight increased significantly from 65.7 & #0;9.6 to 67.2 & #0;9.9 kg (p=0.002). CONCLUSION: Glurenorm was effective for glycemic control but caused weight gain in type 2 diabetic patients. Triglycerides in hypertriglyceridemic patients, and total cholesterol, LDL-C, and HDL-C in hypercholesterolemic patients did not improve after glurenorm treatment. |
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