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題 名 | 天麻活性成分對位羥基苯醇改善學習記憶作用與下視丘-腦下垂體-腎上腺軸之關係=Relationship between the Improving Effects of Active Constituent of Tianma-p-hydroxybenzyl Alcohol and Hypothalamo-Pituitary-Adrenal Axis |
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作 者 | 謝明村; | 書刊名 | 中醫藥年報 |
卷 期 | 17:2 1999.05[民88.05] |
頁 次 | 頁409-442 |
分類號 | 414.5 |
關鍵詞 | 對立羥基苯醇; 被動迴避反應; 下視丘-腦下垂體-腎上腺軸; p-hydroxybenzyl alcohol; Passive avoidance response; Hypothalamo-pituitary-adrenal axis; |
語 文 | 中文(Chinese) |
中文摘要 | 本研究以被動迴避反應,探討周邊暨中樞神經系統在 p-hyroxybenzyl alcohol改 善學習記憶作用所扮演之角色。 最後, 並測定血醣濃度及下視丘 Serotonin 濃度。 p-Hydroxybenzyl alcohol(1 及 5mg/kg) 可改善經靜脈注射 6-OHDA 前處理之 apomorphine 或 cycloheximide 誘發學習記憶障礙, 其作用明顯低於正常動物下之改善作 用;另對 p-Chloroamphetamine 及 apomorphine誘發學習獲得障礙、Cyc1OheXimide誘發記 憶鞏固障礙及 apomorphine 誘發記憶再現障礙之改善作用, 均可因去除腎上腺之前處理而 部份阻斷。 進一步之生化測定上, p-hydroxybenzyl a1cohol 可增加正常大自鼠血中 glucose 之濃度。p-Hydroxybenzy1 a1cohOl 對腦室給予 6-OHDA 或 5,7-DHT 誘發之學習 記憶障礙均具改善作用, 但較對 PCA 誘發學習記憶障礙之改善效果為差。 最後, p-hydroxybenzyl alcohol 對 cycloheximide 誘發學習記憶障礙之改善作用可因下視丘給 予 5, 7-DHT 而減弱, 且若經下視丘給予亦具改善作用; 而在生化測定上, 下視丘給予 p-hydroxybenzyl alcohol 可增加正常大自鼠下視丘區域 serotonin 之濃度。 綜合上述實 驗結果,p-hydroxybenzyl alcohol 之改善學習記憶障礙作用不僅與週邊神經系統或中樞神 經系統均有關連;可能與經腎上腺增加肝醣之再利用及中樞下視丘部位經 serotonergic 接 受器以調節下視丘 - 腦下垂體 - 腎上腺軸之內分泌有關。 |
英文摘要 | In the present study, we investigated the role of the peripheral and central nervous system on the improving effects of @-hydroxybenzyl alcohol (HBA) in the passive avoidance task. Secondly, we assay the plasma glucose levels measured by YSI model 23A Glucose Analyzer, the concentration of serotonin in the hypothalamus measured by microdialysis-high performance liquid chromatography. In the role of peripheral sites, the improving effects of HBA on the APO-induced or CXM-induced memory impairment in 6-OHDA (i.v.). treated rats were smaller than those of HBA in normal rats. Secondly, adrenalectomy partially blocked the improving effects of HBA on PCA-1nduced, CXM-induced and APO-induced memory impairment. In the role of central sites, HBA improved the impairment of learning and memory induced by 6-OHDA or 5,7-DHT (i.c.v. or intrahypothalamal) in rats. Finally, intrahypothalamal injection of HBA improved CXM-induced impairment. Furthermore, biochemical studies also appeared that HBA increased the plasma glucose level and concentration of hypothalamic serotonin in normal rats. From above results, we suggested the improving effects of HBA on the various drugs-induced impairment acted through not only the peripheral also central nervous system. These effects might be related to the increase of plasma glucose levels via the peripheral sites such as sympathetic nervous systems and adrenal gland, and the activities of hypothalamo-pituitary-adrenal axis. |
本系統中英文摘要資訊取自各篇刊載內容。