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題 名 | 玉屏風散對抗過敏及調節免疫因子組織胺、間白素-4之研究=Research on the Anti-Allergy and Regulatory Effects of Yu Ping Feng San on the Immunological Mediators, Histamine and Interleukin-4 |
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作 者 | 鄭國揚; 蔡銘修; 林昭庚; 周昌德; 郭寶錚; | 書刊名 | 中華民國耳鼻喉科醫學會雜誌 |
卷 期 | 33:5 1998.10[民87.10] |
頁 次 | 頁9-19 |
分類號 | 414.5 |
關鍵詞 | 玉屏風散; 過敏性鼻炎; 組織胺; 間白素-4; Yu ping feng san; Allergic rhinitis; Histamine; Interleukin-4; IL-4; |
語 文 | 中文(Chinese) |
中文摘要 | 背景:玉屏風散於臨床上治療過敏性鼻炎已多年,本研究探討玉屏風散及 其組成與晉耆 (非正品,佔台灣市售黃耆 90% 以上市場 ) 於抗過敏及細胞網路之作用,以 期為臨床應用提供科學數據,並為整合中西醫學建立一可行的研究模式。方法: 選取 15 位 健康人 (平均年齡 23.13 ± 5.15 歲 ),9 名女性,6 名男性, 每位抽取 30cc 血液加入 肝素。將方劑組: 玉屏風散 (黃耆: 白朮: 防風 )=1:1:1,中藥組: 黃耆 (正品 )、晉耆 ( 非正品 )、白朮、防風, 各以五種濃度 (5 μ g/ml、 10 μ g/ml、100 μ g/ml、250 μ g/ml、500 μ g/ml),共 25 組分別加入刺激物 (A23187、PHA) 為實驗組, 並以刺激物為 對照組,進行中性白血球釋放組織胺(histamine)與單核細胞釋放間白素 -4(interleukin-4,IL-4) 影響之研究。 實驗中以酵素結合免疫分析法 (ELISA) 測其濃度 , 並使用 Dunnett's ttest 與 LSD 進行統計分析。 結果: 玉屏風散可以有效降低組織胺 (3.22 ± 0.61 mg/ml vs 1.33 ± 0.46 ng/ml; p<0.05)、 間白素 -4(18.43 ± 5.18 pg/ml vs 10.61 ± 0.52pg/ml;p<0.05) 的濃度。 進一步分析顯示:主要由其組成中防風 扮演重要的角色 (Dunnett's t test; p<0.05); 黃耆於濃度≧ 250ug/ml 反而增加組織胺 的濃度 (6.64 ± 2.57 ng/ml vs 14.88 ± 3.78 mg/ml;p<0.05),此外,我們得知抑制間 白 -4 釋放,晉耆雖比其它三味中藥少 (least significant difference; p<0.05),但並 沒有增組織胺作用。結論:本研究顯示玉屏風散具有抑制組織胺及間白素 -4 作用,防風扮 演重要角色。以開發新藥觀點而言,晉耆在抗過敏方面比黃耆適合;至於臨床上治療過敏性 鼻炎,是否有相同結果,現正進一步研究中。 |
英文摘要 | Background:Yu Ping Feng San has been used in the clinical treatment of allergic rhinitis for many years. This study investigated the anti-allergic action of Yu ping Feng San, its active ingredients, and Chingqi (a substitute for the active ingredient, Huangqi, that is not considered an authentic ingredient in traditional Chinese medicine but which now substiutes for Huangqi over 90% of prescription in Taiwan) on the cytokine network. Our purpose was to produce scientific data for the clinical use of these compounds and a practical research model for the integration of Chinese and western approaches to medicine. Methods: Fifteen healthy individuals, 9 women and 6 men, were selected for participation in this study (average age, 23.13 ± 5.15 years). Each participant donated 30 ml of blood, to which heparin was added. The medicines tested included Yu Ping Feng San (Huangqi, Baizhu and Fangfeng in a 1:1:1 ratio), Huangqi, Chingqi, Baizhu, and Fangfeng. For the experimental group, stimulants (A23187, PHA) were added to each of 25 samples, comprised of 5 different concentrations (5 μ g/ml, 10 μ g/ml, 100 μ g/ml, 250 μ g/ml, and 500 μ g/ml) of the sample medicine. The stimulants themselves comprised the control group. The effect of these compounds on the secretion of histamine from neutrophils and the secretion of interleukin-4 (IL-4) from mononuclear cells was then studied. Concentrations were measured using enzyme-linked immunosorbent assay (ELISA) , and all statistical analyses were carried out with Dunnett's t test and LSD. Results: Yu Ping Feng San effectively reduced the concentrations of histamine (3.22 ± 0.61 mg/ml vs 1.33 ± 0.46 ng/ml: p<0.05) and IL-4 (18.43 ± 5.18 pg/ml vs 10.61 ± 0.52 pg/ml: p<0.05). Further analysis showed that Fangfeng, played a major role (Dunnett's t test: p<0.05): Huangqi at concentrations greater than or equal to 250 μ g/ml actually increased the concentration of histamine (6.64 ± 2.57 ng/ml vs 14.88 ± 3.78 ng/ml: p <0.05). In addition, we also found that although Chingqi resulted in less inhibition of IL-4 (least significant difference: p<0.05) than the other three active ingredients, it did not increase histamine levels. Conclusions: Our study showed that Yu Ping Feng San exhibits an inhibitory effect on histamine and IL-4, with Fangfeng playing a major role. In the search for new therapeutic medicines, Chingqi apprears to be more suitalbe than Huangqi in producing antiallergy action. Further research is currently underway to determine whether the same result is obtained in the clinical treatment of allergic rhinitis. |
本系統中英文摘要資訊取自各篇刊載內容。