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題名 | Establishment and Characterization of a Cell Line (HCDB-1) Derived from a Hamster Buccal Pouch Carcinoma Induced by DMBA and Taiwanese Betel Quid Extract=由DMBA及臺灣檳榔嚼塊萃取物共同誘發的倉鼠頰囊癌所建立之細胞株(HCDB-1)之定性 |
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作者 | 林姝君; 張國威; 張哲壽; 余炘遠; 趙守一; 黃穰基; Lin, Shu-chun; Chang, Kuo-wei; Chang, Che-shoa; Yu, Sin-yuen; Chao, Shou-yee; Wong, Yong-kie; |
期刊 | Proceedings of the National Science Council : Part B, Life Science |
出版日期 | 20000700 |
卷期 | 24:3 2000.07[民89.07] |
頁次 | 頁129-135 |
分類號 | 416.94 |
語文 | eng |
關鍵詞 | 檳榔嚼塊萃取物; 倉鼠; 頰囊癌; 細胞株; Betel quid; Carcinoma; DMBA; Hamster; p53; |
英文摘要 | This study identified that the carcinogenesis of hamster buccal pouch (HBP) induced by 7, 12-dimethyl-benz[a]anthracene (DMBA) was greatly enhanced (18 folds) by a combination treatment with Taiwanese betel quid (BQ) extract. A new cell line, HCDB-1, has been established from induced carcinomas. The cultured monolayer cells were epithelioid in shape with irregular nuclei. They demonstrated abundant cytokeratin and tonofilaments; however, ultrastructural well-organized desmosomes were lacking. The HCDB-1 cell exhibited population doubling in 19 h and was highly tumorigenic in nude mice. A C?T transition at codon 141 (Ala to Val) of the p53 gene was detected in this cell. This mutation is equivalent to a specific temperature-sensitive mouse p53Ala135Val mutant that causes transformation by shifting to 37.5?. HCDB-1 is the first cell line established from the HBP model of oral carcinogenesis induced by DMBA/Taiwanese BQ extract. It might be valuable for exploring the molecular pathogenesis of oral cancer. |
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