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題名 | Enhanced Inhibitory Effect from Interaction of Curcumin with Amphotericin B or Fluconazole Against Candida Species=薑黃素與Amphotericin B或Fluconazole共同使用增強抑制念珠菌之功效 |
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作者 | 曹世明; 殷梅津; | 書刊名 | 藥物食品分析 |
卷期 | 8:3 2000.09[民89.09] |
頁次 | 頁208-212 |
分類號 | 414.5 |
關鍵詞 | 薑黃素; 念珠菌; Curcumin; Amphotericin B; Fluconazole; Candida species; |
語文 | 英文(English) |
英文摘要 | The antifungal activity of curcumin against seven Candida species was studied by investigating the growth of 200 clinical isolates from patients with fungal infections. The MICs of curcumin against Candida species were in the range of 32 to 128 mg/mL. The interaction of curcumin with amphotericin B or fluconazole against these fungi was determined by FIC index and % reduction in turbidity. Synergistic effect was shown in all combinations of curcumin and amphotericin B; whereas both synergistic and additive effects were observed in the combinations of curcumin and fluconazole. This evidence suggests that when curcumin is combined with amphotericin B or fluconazole, it could provide greater fungicidal effects for the treatment of systemic fungal infections such as candidiasis and candidemia. |
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