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題 名 | 醒神開竅針刺法對腦缺血大鼠動物行為的效應=Effects of "Xing Shen Kai Qiao" Acupuncture on Animal Behavior in Ischemic Rat |
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作 者 | 高宗桂; 林昭庚; 郭重雄; 張永賢; 謝慶良; 彭文煌; | 書刊名 | 中國醫藥科學雜誌 |
卷 期 | 1:2 2000.06[民89.06] |
頁 次 | 頁87-96 |
分類號 | 413.91 |
關鍵詞 | 記憶能力; 醒神開竅針法; 缺血性中風; Acupuncture; Xing Shen Kai Qqiao; Memory; Ischemic stroke; Noradrenaline; Dopamine; Serotonin; |
語 文 | 中文(Chinese) |
中文摘要 | 本實驗將大鼠分為針刺組、缺血模型組、假手術組與正常組。針刺組 採用「醒神開竅」針刺法予以治療。以單側中腦動脈及雙側頸總動脈阻塞做缺血 性中風造模,在缺血24小時、72小時使用「條件反射測定裝置」與紅外線矩陣 式動物行為測量系統進行動物行為觀察及自發運動量之比較,探查醒神開竅針刺 法在缺血性中風後,是否扮演著提高學習記憶能力之角色。另於第48小時取其 大腦,以高速液相層析儀(HPLC)測量左右大腦皮質noradrenaline(NA)、dopamine (DA)、serotonin(5-HT)的濃度。假手術組僅作顱骨咬開與頸切開暴露右中腦 動脈與左右頸動脈,其他與實驗組相同;非針刺組則於造模後未經針刺;正常組 不做手術處理。 實驗結果顯示,缺血模型組之學習記憶能力、局部自發運動量與NA、DA、 5-HT等三種腦部神經傳遞物質濃度皆比正常組或假手術組低,而有經過針刺的 缺血組其參數皆比單純缺血組有統計意義的提高。結論:醒神開竅針刺法對大鼠 腦缺血所致的記憶喪失與肢體運動能力皆有明顯改善效果,推測醒神開竅針刺法 對於缺血性痴呆與憂鬱症具有治療作用。 |
英文摘要 | Adult ,male Sprague-Dawley rats were devided into Acupuncture, Non- Acupuncture , Sham operation and Normal groups. Besides the latest groups , animals were subjected occlusions of bilateral common carotid artery and middle cranial artery for 24 hours and 72 hours . Xing Shen Kai Qiao acupuncture was performed at the 48th hour after occlusions. "Conditioned-response determine device" was used to detect memory and locomotor activity of ischemic stroke rats.The cortical concentration of noradrenaline,dopamine and serotonin were determined by High Performance Liquid Chromatography with electrochemical detector . The results showed that passive escape response,locomotor activity and concentration of cerebral cortical monoamines of ischemic group are lower than those of normal group and also those of acupuncture group. Conclusion:Xing Shen Kai Qiao acupuncture improved the motor activity and memory ability, and increased concentration of cerebral biogenic monoamines of ischemic rats ,These findings may suggest improve dementia and anxiety . |
本系統中英文摘要資訊取自各篇刊載內容。