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| 題 名 | Relationship of Serum Lactate Dehydrogenase, Creatine Kinase, Aspartate Aminotransferase Concentrations and Severe Intraventricular Hemorrhage/Leukomalacia in Very Low Birth Body Weight Preterm Neonates=很低體重早產兒的血清中乳酸脫氫酶(LDH),肌酸催化酶(CK),天門酸轉氨基酶(AST)之濃度與嚴重腦室出血或腦室旁皮質軟化之關係 |
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| 作 者 | 何茂霖; 蘇本華; 陳家玉; | 書刊名 | 臺灣兒科醫學會雜誌 |
| 卷 期 | 41:3 民89.05-06 |
| 頁 次 | 頁129-132+166 |
| 分類號 | 417.5171 |
| 關鍵詞 | 很低體重早產兒; 乳酸脫氫酶; 肌酸催化酶; 天門酸轉氨基酶; 腦室出血; VLBW neonate; AST; LDH; CK; Intraventricular hemorrhage; |
| 語 文 | 英文(English) |
| 中文摘要 | 血清酵素濃底的評估常被應用於疾病診斷,此實驗的目的是設計來決定很低全重早産兒出生第一天內血清中LDH,CK,AST的濃度與發生嚴重腦室出血或腦室出血或腦室旁皮質軟的危險相關性。全部共有81位很低體重早産兒(出生體重小於1500公克)進入實驗,吾人使用腦部超音波評估腦室出血,且持續每週兩次,直到懷孕週數大於40週或體重大於2300公克。實驗結果發現血清中LDH及CK的濃度與發生嚴重腦室出血或腦室旁皮質軟化有明顯的危險相關性(p<0.05),但AST的濃度則無統計學上之意義。參照血清中LDH及CK濃度90百分比(1933IU/L處652IU、L)爲臨界點,預測值亦顯示敏感性爲76.9%、專一性爲89.7%及陰性預測值爲95.3%;所以,很低體重早産兒出生第一天內血清中LDH及CK濃度昇高者,其發生嚴重腦室血或腦室旁皮質軟化的危險性做一日和尚撞一天鍾大爲提高。 |
| 英文摘要 | Estimations of serum enzyme values are widely employed as valuable diagnostic aids in diseases. Most commonly employed enzymes include Aspartate amninotransferase (AST, Lactate dehydrogenase (LDH), and Creatine kinase (CK). The study was designed to determine the relationship of elevated postnatal serum LDH, CK, and AST concentrations within the first day of life and the risk of suffering severe intraventricular hemorrhage (IVH) and/or periventricular leukotnalacia (PVL) in VLBW preterm newborns. 81 preterm neonates whose birth body weight <1500gm were enrolled. Serums were obtained far measurement within the first postnatal day. Cranial ultrasound scans were performed twice per week after birth until their body weight was above 2300gm or postconceptional age above 40 weeks. Significant difference was noted in serum LDH and CK concentrations in severe IVH/PVL infants (p<0.05). No difference was found in serum AST values. Compared with the cut-off values of 1933 IU/L of LDH concentration and 652 IU/L of CK, the predictive values revealed a sensitivity, specificity, negative predictive value and positive predictive value of 76.9%, 89.7%, 95.3% and 58.8%, respectively. In conclusion, higher serum LDH and/or CK concentrations within the first day of life were associated with risk for development of severe JVH/PVL. |
本系統中英文摘要資訊取自各篇刊載內容。