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題名 | Inclusion Complex Formation of Alkannin/Shikonin Enantiomers in Hydroxypropy1-β-Cyclodextrin=紫草素及氫氧丙烷基-β-環糊精之包接化合物的形成 |
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作 者 | 陳福安; 吳安邦; 鄭慧文; 陳朝洋; | 書刊名 | 大仁學報 |
卷期 | 18 2000.05[民89.05] |
頁次 | 頁1-9 |
分類號 | 418.4 |
關鍵詞 | 紫草素; 氫氧丙烷基-β-環糊精; 包接化合物; Alkannin shikonin enantiomers; Hydroxypropyl-β-cyclodextrin; Inclusion complex; |
語文 | 英文(English) |
中文摘要 | 紫草素(Alkannin/shikonin enantomers)為紫草(Shikon, Macrotomia euchroma)之主藥理活性成份,經熱分析儀、傅式紅外線光譜儀及粉末X-光繞射儀分析發弄紫草素會與氫氧丙烷基-β-環糊精(Hydroxypropyl-β-cyclodextrin)形成包括化合物後,經熱分析驗證並不會產生熱分解。因此氫氧丙烷基-β-環糊精可有效提升紫草素的熱安定性。此包托化合物以粉末X-光繞射儀分析後發現此紫草素及氫氧丙烷基-β-環糊精更不具結晶性。 |
英文摘要 | In the present study, we report that by using differential scanning calorimetry (DSC), fourier transform infrared spectroscopy (FTIR), and powder X-ray diffraction analysis, alkannin/shikonin enatiomers (A/S), the main pharmacologically active components of Shikon (Macrotomia euchroma), were found to form inclusion complexes with hydroxypropy1-β-cyclodextrin (HPCD). Through inclusion complexation with HPCD, the thermal decomposition of A/S was not observed as demonstrated by DSC thermograms. The inclusion complex was found to be significantly less crystalline than any of the pure components based on the powder X-ray diffraction analysis. |
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