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題 名 | 運動後葡萄糖供應與禁食對肌肉肝醣儲存與GLUT4基因表現的影響=Effect of Fasting and Glucose Supplementation on Glycogen Storage and GLUT4 Gene Expression in Skeletal Muscle |
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作 者 | 郭家驊; 邱毓川; 陳秀華; 黃心怡; 秦玉芳; | 書刊名 | 大專體育學刊 |
卷 期 | 2:1 2000.06[民89.06] |
頁 次 | 頁37-45 |
分類號 | 528.9013 |
關鍵詞 | 游泳; 肝醣超補現象; GLUMT4 mRNA轉譯; GLUT4蛋白; Swimming; Glycogen supercompensation; GLUT4 mRNA translation; GLUT4 protein; |
語 文 | 中文(Chinese) |
中文摘要 | 三十年前古典肝醣超補(glycogen supercompensation)研究發現,在運動造成肌肉肝醣減少之後是否有延遲的碳水化合物攝取,可以對肌肉的肝醣超補之效果產生不同的影響(Ahlborg等,1967)。由於先前筆者發現肝醣儲存的增加與GLUT4基因的誘發有關(Kuo等,1999),本研究的首要目的為觀察運動後給予葡萄糖或禁食,對於葡萄糖運輸蛋白GLUT4的表現的影響。在動物運動後十六小時的恢復時間,葡萄攝取使肌肉(red gastrocnemius)GLUT4蛋白質表現數量增加約90%,而GLUT4 mRNA僅增加了40%左右。相同時間內禁食組(僅維持水份供應)抑制運動誘發導致的GLUT4蛋白的表現量(僅增加40%)。但GLUT4 mRNA的表現數量卻大幅累積至比對照組的高出80-90%左右。在運動後同樣量的葡萄糖攝取使得肌肉肝醣比對照組多出78%。本研究證明了運動後葡萄糖攝取增加GLUT4 mRNA轉譯活生,進而造成了GLUT4蛋白數量增加。更重要的是運動後如果沒有及時的醣類攝取,可能使得肌肉葡萄糖運輸蛋白的表現系統更敏感化。當葡萄糖的攝取誘發GLUT4 mRNA轉譯活性時,大量的GLUT4 mRNA存在對於轉譯後GLUT4蛋白數量的增加也許加更有利。另外本研究發現肌肉肝醣的超補現象似乎受到運動後GLUT4基因表現的影響。 |
英文摘要 | Thirty years age, research has shown that a delayed carbohydrate supplementation can produce a better glycogen supercompensation in the exercised muscles (Ahlborg et al., 1967). We have previously found that glycogen supercompensation may related to a transient exercise-induced GLUT4 expression (Kuo et al.,1999). Therefore, in this study effects of post-exercise fasting versus glucose supplememntation on GLUT4 expression in skeletal muscle were studied 16 hours after a glycogen depleting exercise. An immediate post-exercise glucose load elevated GLUT4 protein by 90% with a small GLUT4 mRNA elevation (approximately 40% above control) in red gastronomies muscle. Glycogen storage was not supercompensated in exercise-fasted rats. Glycogen storage from the exercise-glucose muscle was 78% above control after a post-exercise carbonydrate load. No significant increase in muscle GLUT4 protein level was detected in the sedentary-control muscle. The current study indicates that glucose supplementation accelerates the exercise-induced GLUT4 expression by activating translation mechanisms. Furthermore, our results suggest that the post-exercise fasting may function to facilitate or sensitize skeletal muscle GLUT4 protein expression by upregulating GLUT4 mRNA which then awaits glucose stimulation to activate the process of translation into GLUT4 protein. Finally, the post-exercise glycogen supercompensation may be partially due to an elevated GLUT4 protein expression in skeleteal muscle. |
本系統中英文摘要資訊取自各篇刊載內容。