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頁籤選單縮合
題名 | Immunohistochemical Study of Opioid Receptors after Chronic Morphine Treatment in Rats=以兔疫組織化學法在大白鼠探討慢性給予嗎啡對類鴉片受體之影響 |
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作者姓名(中文) | 陶寶綠; 牛河山; 呂偉明; 王順德; | 書刊名 | Proceedings of the National Science Council : Part B, Life Science |
卷期 | 24:1 2000.01[民89.01] |
頁次 | 頁14-19 |
分類號 | 418.2132 |
關鍵詞 | 兔疫組織化學法; 嗎啡; 類鴉片受體; Morphine; Antinociception; Tolerance; Opioid receptor; Down-regulation; Immunohistochemistry; |
語文 | 英文(English) |
英文摘要 | Previously, we have used the biochemical receptor binding method to investigate whether down-regulation of the opioid receptor is a mechanism for morphine tolerance, and we were led to a negative conclusion. In the current study, we further used immunohistochemistry to reinvestigate this issue. Male Sprague-Dawley rats (250-300g) were chronically treated with morphine s.c. for 2, 4 or 6 days, using an escalating dosage paradigm (5-45mg), which resulted in a 1.8 to 4.0-fold increase in AD50. Rat brains were removed, frozen, coronally sectioned (14?) and processed for ? or d-opioid receptor immunohistochemistry using the Avidin-Biotin Complex (ABC) method. No significant decrease in ?opioid receptor (MOR) immunodensity was found in most of the brain regions, which were enriched with MOR after chronic treatment with morphine except for the anteroventral thalamic nucleus in the ventrolateral part (AVVL). No significant change in d-opioid receptor (DOR) immunodensity after chronic treatment with morphine was found either. Therefore, our conclusion is that down regulation of opioid receptors may not be an important mechanism for morphine tolerance. |
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