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題 名 | Detection of Circulating Tumor Cells in Venous Blood of Nasopharyngeal Carcinoma Patients by Nested Reverse Transcriptase-Polymerase Chain Reaction=以巢式反轉錄酶--聚合酶連鎖反應研究鼻咽癌病人血液中擴散癌細胞之偵測 |
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作 者 | 林進清; 蔡家興; 王文綺; 詹建勝; | 書刊名 | The Kaohsiung Journal of Medical Sciences |
卷 期 | 16:1 2000.01[民89.01] |
頁 次 | 頁1-8 |
分類號 | 416.879 |
關鍵詞 | 巢式反轉錄酶-聚合酶連鎖反應; 鼻咽癌; 血液; 癌細胞; 放射線敏感; Nasopharyngeal carcinoma; Cytokeratin; Polymerase chain reaction; |
語 文 | 英文(English) |
中文摘要 | 鼻咽癌對放射線敏感,近年來由於放射腫瘤學進步,腫瘤局部控制率提高,治療 失敗的主要原因是遠處轉移,本研究目的是建立巢式反轉錄西-聚合醃連鎖反應,早期偵測 鼻咽癌病人血液中癌細胞之可行性。共有40位經病理切片証貿為兵咽癌病患及20位健康人進 入本研究,抽取病人靜脈血10毫升,萃取血液細胞RNA,選用Cytokeratin19(CK-19)mRNA 為標幟,進行巢式反轉錄醃-聚合醜連鎖反應,初步結果顯示:治療過無病存活者9例皆呈 陰性反應。早期者(第一、二、三期)8例中2例呈陽性反應(25%),晚期但無遠處轉移者 第四期MO)15例中6例呈陽性反應(40.0%),8例証實已發生遼處轉移者6例呈陽性反應 (75.0%),20位健康人皆呈陰性反應,以上數據頭示:本系統之陽性偵測率,隨鼻咽癌之嚴 重度增加有增高之趨勢,但其差異未達統計學意義(P=0.11),值得長期追蹤病人並評估 血液中CK-l9陽性者,將來發生遠處轉移以及預後之關聯性,以確定其臨床應用價值。 |
英文摘要 | Nasopharyngeal carcinoma (NPC) is a radiosensitive tumor. Because of recent advances in radiation oncology, distant metastasis has become the predominant failure site after adequate radiotherapy. The purpose of this study is to establish a nested reverse transcriptase-polymerase chain reaction (RT-PCR) system and to evaluate the potential of cytokeratin 19 (CK-19) mRNA as a target for detecting micrometastasis in the blood of NPC patients. Venous blood samples from 40 patients with biopsy-proven NPC (25 previously untreated and 15 after radiotherapy) and 20 healthy volunteers were tested. We divided the 40 patients into 4 groups: cured, early stage, advanced stage, and metastasized, according to results of clinical staging workup. Under our nested RT-PCR experimental conditions, 2 of 8 early stage patients (25.0%), 6 of 15 advanced stage patients (40%), and 6 of 8 patients with distant metastasis (75%) had CK-19 positive cells in peripheral blood (P=0.11). No CK-19 positive cells were detected in 9 "cured" patients and 20 healthy volunteers. Our data indicated that the positive detection rate for CK-19 mRNA in peripheral blood increased as the clinical stage of disease increased, but the difference did not reach statistical significance. Longer follow-up is needed to assess the significance of CK-19 mRNA in blood, as well as its relation to subsequent metastasis and prognosis of NPC. |
本系統中英文摘要資訊取自各篇刊載內容。