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| 題 名 | Nasopharyngeal Carcinoma with Leptomeningeal Dissemination: Case Report=鼻咽癌合併軟腦膜內擴散:病例報告 |
|---|---|
| 作 者 | 王重榮; 汪昶佑; | 書刊名 | 長庚醫學 |
| 卷 期 | 23:2 2000.02[民89.02] |
| 頁 次 | 頁118-122 |
| 分類號 | 416.879 |
| 關鍵詞 | 鼻咽癌; 放射治療; 腦膜癌病; Nasopharyngeal carcinoma; Radiation therapy; Meningeal carcinomatosis; |
| 語 文 | 英文(English) |
| 英文摘要 | Nasopharyngeal carcinoma (NPC) is a highly prevalent malignancy in southeast China, Hong Kong, and Taiwan. Spread of this tumor is known to occur via three main routes, i.e., local invasion of adjacent structures, regional metastasis to neck nodes, and hematogenous metastasis to distant organs. In this report, we describe a rare case of NPC disseminated via the leptomeninges, so called meningeal carcinomatosis (MC). The patient was a 62 year-old man who presented with multiple cranial nerve palsies and a headache, and was diagnosed with NPC in August 1988. The primary tumor regressed completely after induction chemotherapy and radiation therapy. Computerized tomography (CT) 17 months after radiation therapy showed multiple enhanced nodules scattered along the temporal meninges. The nodules increased in number and size in the subsequent CT scan 4 months later. The patient declined further invasive procedures and oncologic treatments, and he expired at home 9 months after the development of MC. It is speculated that perineural invasion and access to the subarachnoid space was the major cause of MC in this case. The case, although rare, possibly highlights a rare route of tumor dissemination in NPC. |
本系統中英文摘要資訊取自各篇刊載內容。