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頁籤選單縮合
題名 | Regulation and Functions of c-Jun N-Terminal Kinase/Stress-Activated Protein Kinase=c-Jun N-Terminal Kinase/Stress-Activated Protein Kinase的調節與功能 |
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作者 | 王子豪; 王馨世; 宋永魁; | 書刊名 | 長庚醫學 |
卷期 | 23:2 2000.02[民89.02] |
頁次 | 頁57-72 |
分類號 | 415.132 |
關鍵詞 | 細胞凋亡; 訊息傳遞; Mitogen-activated protein kinase; MAPK; c-Jun N-terminal kinase apoptosis; JNK; Stress-activated protein kinase; Apoptosis; SAPK; Signal transduction; |
語文 | 英文(English) |
英文摘要 | The cell uses a complex signal transduction network both to respond to changes in its microenvironment and to integrate all of its intracellular signals. Actions of various signals in the cellular signal transduction network converge at the mitogen-activated protein kinase (MAPK) cascades, which lead to and activate transcription factors in the nucleus and other effectors throughout the cell. Extracellular signal-regulated kinases (ERKs), c-Jun N-terminal kinases/stress- activated protein kinases (JNK/SAPK), and p38 are some of the better characterized members of the MAPK family. Unlike ERK mainly responding to mitogens, JNK/SAPK was originally identified as a stress-related kinase and it has been extensively demonstrated to be associated with apoptosis. However, recent studies have further indicated that JNK/SAPK also has many functions other than the promotion of apoptosis. The repertoire of the JNK/SAPK pathway is wide-ranging, and its functions can vary, and even oppose each other, depending on the cell types and stimuli. It remains a challenge for biomedical scientists to elucidate the distinct role of JNK/SAPK in each model system. |
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