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頁籤選單縮合
題 名 | Common Hemoglobin Variants in Southern Taiwan and Their Effect on the Determination of HbA1c by Ion-exchange High-performance Liquid Chromatography=南臺灣常見的變異血色素以及它們對以離子交換高效液相色譜法檢驗糖化血色素的影響 |
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作 者 | 朱志勳; 林興中; 李鎮堃; 王玫君; 吳志成; 孫群欽; 莊明儒; | 書刊名 | Journal of the Chinese Medical Association |
卷 期 | 72:7 2009.07[民98.07] |
頁 次 | 頁362-367+CA67 |
分類號 | 414.91 |
關鍵詞 | Boronate親合高效液相色譜法; 胎兒血色素; 糖化血色素; Primus CLC-385; Tosoh HLC-723 G7; Boronate-affinity HPLC; Fetal hemoglobin; Glycohemoglobin; |
語 文 | 英文(English) |
英文摘要 | Background: Patients with hemoglobin (Hb) variants may produce false HbA1c measurement. This study aimed to detect the common Hb variants in southern Taiwan and to evaluate their effect on the determination of HbA1c. Methods: A total of 1,434 samples collected for HbA1c measurement at Kaohsiung Veterans General Hospital in southern Taiwan in March 2008 were submitted for Hb variant analysis by Primus CLC-385. HbA1c measurements were obtained using ion-exchange high-performance liquid chromatography (HPLC) (Tosoh HLC-723 G7) for routine analysis. Patients identified with Hb variants were recalled for boronate-affinity HPLC analysis. The values of estimated average glucose (eAG) were converted from HbA1c. Values of eAG-FPG, calculated by eAG minus fasting plasma glucose (FPG), were compared to estimate the accuracy of HbA1c measurement in patients with Hb variants. Results: Among the 1,434 patients, the mean ± standard deviation of FPG was 162.8 ± 60.5 mg/dL, HbA1c was 8.28 ± 1.97%, and eAG was 190.9 ± 56.6 mg/dL. Five Hb variants were detected in 11 patients, the incidence being 0.76%. Hb J was identified in 4 patients, Hb G in 2 patients, Hb E in 1 patient, Hb owari in 3 patients, and high fetal hemoglobin (HbF) in 1 patient. Abnormal HPLC chromatograms were seen among the patients with Hb J, E, G and HbF, but not in the patients with Hb owari. In patients with Hb variants, FPG was 149.5 ± 39.9 mg/dL, HbA1c was 7.29 ± 2.01%, and eAG was 162.5 ± 57.7 mg/dL. Lower values of eAG-FPG may have occurred in the patients with Hb J and E, and in those with high HbF. On scattergrams of the relationship between HbA1c and FPG, the plots of Hb J, E and high HbF lay below the regression line of non-Hb variants. Inconsistent Hb values between both methods were only observed among some samples of patients with Hb variants. Conclusion: The existence of Hb variants may result in false HbA1c measurement. The possible presence of spuriously low HbA1c levels or abnormal HPLC chromatograms by using ion-exchange methods should be kept in mind. |
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