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題 名 | 麻杏甘石湯對塵蟍誘發氣喘天竺鼠之影響=The Effect of Ma-Xing-Gan-Shi-Tang on Dermatophagoides Pteronyssinus-Induced Asthmatic Guinea Pig |
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作 者 | 高尚德; 張朝棟; 薛尊仁; 賴義雄; 林昭庚; | 書刊名 | 中臺灣醫學科學雜誌 |
卷 期 | 4:1 1999.03[民88.03] |
頁 次 | 頁62-68 |
分類號 | 414.5 |
關鍵詞 | 立即性氣喘反應; 發炎細胞; 遲發性氣喘反應; 麻杏甘石湯; Immediate asthmatic responses; Inflammatory cell; Late asthmatic responses; Ma-xing-gan-shi-tang; |
語 文 | 中文(Chinese) |
中文摘要 | 過敏性氣喘為目前台灣最常見的小兒慢性疾病,其中超過90%的孩童對塵 之皮膚試驗呈陽性反應。本研究以純化的家塵 (Dermatophagoides pteronyssinus, DerP)蛋質為抗原誘發天竺鼠,建立天竺鼠氣喘動物模式,評估麻杏甘石湯對氣喘天竺鼠的影響。天竺鼠於第0及第7日接受腹腔注射100μg純化DerP蛋白質致敏,於第21日以4 mg/ml純化DerP蛋白質溶液激發,實驗組於激發前2小時、1小時,激發後15分鐘灌服麻杏甘石湯,控制組灌服生理食鹽水,基準組則致敏,但不激發。各組於激發後各時間點進行氣管肺泡沖洗液分析、呼吸道阻力測量及肺病理組織檢查。結果顯示,麻杏甘石湯能降低激發後5分鐘至72小時各時間點呼吸道阻力及1、6小時肺泡沖洗液中嗜中性白血球之百分比,但對嗜伊紅性白血球無影響。病理組織檢查發現,實驗組天竺鼠在呼吸道平滑肌附近及往上皮細胞方向沒有明顯的嗜中性及嗜酸性白血球浸潤,控制組則出現嗜中性及嗜酸性白血球浸潤。綜合以上結果,我們認為麻杏甘石湯有抑制立即性氣喘反應及遲發性氣喘反應的作用,並能降低立即性反應期呼吸道嗜中性白血球的浸潤,其詳細機轉有待進一步研究。 |
英文摘要 | Allergic asthma is one of the most common chronic pediatric diseases in Taiwan. According to an epidemiology study of asthma in schoolchildren in Taipei, the prevalence of asthma increased from 1.3% in 1974 to 10.8% in 1994. More than 90% of children with asthma have positive skin test responses to house dust mite (HDM), and Dermatophagoides pteronyssinus (DerP) was found to be the dominant species. Ma-Xing-Gan-Shi-Tang (MXGST), a traditional Chinese medicine, has been used in treatment of the bronchial asthma for several centuries. To understand the mechanism of antiasthmatic property of MXGST, a guinea pig model of allergic asthma was used to investigate the effect of MXGST on DerP-induced early and late asthmatic responses and airway inflammation. The results showed administration of MXGST significantly inhibited the antigen induced immediate asthmatic responses and late asthmatic responses, and inhibited the increase in percent of neutrophil in bronchoalveolar lavage fluid at 1h, 6h after antigen challenge. Histopathologic examination showed MXGST suppressed the neutrophil infiltration into the airway at early phase. Otherwise, MXGST cannot suppress the eosinophil infiltration into the airway at late phase. In conclusion, MXGST does have an effect on asthma treatment, which could relieve that bronchoconstriction and decrease neutrophil infiltration into airway. The precise mechanism of action of MXGST in asthma remains to be elucidated. |
本系統中英文摘要資訊取自各篇刊載內容。