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題 名 | Sequential Combination of 5-Fluorouracil and Cisplatin (CDDP) with Concurrent Administration of Leucovorin and Dipyridamole for Squamous-Cell Lung Cancer:A Report of Two Cases=以時序性的5-Fluorouracil與Cisplatin (CDDP)化學療法合併Leucovorin及Dipyridamole治療肺鱗狀細胞癌--二病例報告 |
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作 者 | 朱芳業; 趙崇良; 李世偉; 謝宏浩; 賴敏謙; | 書刊名 | 胸腔醫學 |
卷 期 | 12:1 1997.03[民86.03] |
頁 次 | 頁28-33 |
分類號 | 415.468 |
關鍵詞 | 時序性化學療法; 肺鱗狀細胞癌; Sequential chemotherapy; Squamous-cell lung carcinoma; |
語 文 | 英文(English) |
中文摘要 | 化學治療對於無法手術或轉移性的肺非小細胞癌病患的治療效果仍然不佳。我們 在本文中報告以時序性的 5-Fluorouracil(5-FU) 與 Cisplatin (CDDP) 化學療法合併 Leuconorin 及 Dipyridamole 治療兩位無法手術的肺鱗狀細胞癌病患的經驗。 個案一是一 位六十五歲男性病患因左下肺葉無症狀的空洞性腫塊於八十二年八月在本院接受左下肺葉切 除手術,病理報告顯示第一期 (T2NOMO) 肺鱗狀細胞癌。術後兩年發現有局部復發及骨轉移 (第四期 ),我們給予上述的化學療法,經過兩療程治療,腫塊直徑縮小了一半以上。 雖然 追病患因腸胃道的副作用拒絕再接受化學治療,在治療後 19 個月,他仍然過著正常的生活 。個案二是一位七十三歲男性病患因反覆肺炎在某醫院接受治療兩次,因症狀在出院後不久 即復發,故至本院。 經詳細評估檢查證實患有第三 B 期 (T4N2MO) 肺鱗狀細胞癌,我們給 予如個案一之化學治療,治療二個療程後,腫瘤完全消失,在追蹤的x光片上無法找到腫瘤 的影像。目前這病患正準備接受後續的療程。在治療過程中,兩者皆沒有發生明顯的骨髓抑 制及腎毒性,僅有一過性輕微的黏膜炎及腸胃不適。我們認為這個治療法值得進一步研究。 |
英文摘要 | The results of chemotherapy for treatment of unresectable or metastatic non-small-cell lung cancer remain disappointing. We treated two patients with unresectable squamous-cell lung caners using seuqential chemotherapy involving 5-fluorouracil (5-FU) and cisplatin (CDDP) with leucovoring and dipyridamole as a biochemical modulator for 5-FU. The regimen was repeated every 3 weeks and was scheduled for 6 courses. The first patient was a 65-year-old man who had a left lower lobe lobectomy for an asymptomatic cavitary lesion in August 1993. The sugical stging was squamous-cell carcinoma, stage Ⅰ (T2NOMO). Recruuence over the left hilar area with bone metastasis (stage Ⅵ ) was found 2 years later. He was then treated with the proposed regimen. After two courses of chemotherapy, Chest X-rays have shwoned the lung mass diameter had been redued by more than 50%. He refused further chemotherapy courses because of naused and mucositis side effects.He is living and well thus far,19 months after the second course of chemotherapy,though follow-up chest X-rays have shown gradual enlargement of the tumor. The second patient was a 73-year-old male victim of previously untreated lung cancer. The clinical staging was squzmous-cell lung cancer,stage Ⅲ b (T4N2MO). He also treated with the proposed regimen. Follow-up chest x-rays, taken just before the beginning of the third course of chemotherapy, showed complete remission. He also suffered mild mucositis and gastrointestinal upset. He is well now and is scheduled to undergo further chemotherapy. No obvious myelosupp-ression or nephrotoxicity was observed in either of these patients. This regimen appears to be potentially useful for squamous-cell lung cancer treatemnt and warrants futher clinical study. |
本系統中英文摘要資訊取自各篇刊載內容。