| The soft tissue around osseointegrated dental implant plays a very important role to the success of implants. Here we report a case: a Japanese male patient suffered oral squamous cell carcinoma and recieved segmental resecrtion of the mandible and neck dissection. Rehabilitation was performed by vascularized fibular bone graft. After 18 months, there was no sign of recurrence, then Branemark dental implants were installed. After 6 months, flatten lower ridge without vestibule was noted the skin flap was thick and rough, hairy, sweaty with bad odor in the oral cavity. We decided to improve the condition by doing vestibuloplasty and replacement of the skin graft with artificial culture mucosa (ACM). We took healthy oral mucosa specimen from the same patient, and sent it to the laboratory for cell culture. After 3-week culture, the ACM was about 1000 times of the original size. At the second stage of dental implant surgery, we performed the vestibuloplasty first, connected the abutment, then covered the periosteum by the ACM. One week later, the ACM was completely attached to the periosteum, the previous problems were solved. Finally, the patient was referred to the prosthodontist for further treatment.