頁籤選單縮合
題名 | Chemistry of Hypusine Formation on Eukaryotic Initiation Factor 5A in Biological Systems |
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作者姓名(中文) | 陳光宇; 饒立恩; | 書刊名 | Journal of the Chinese Chemical Society |
卷期 | 46:5 1999.10[民88.10] |
頁次 | 頁727-734 |
分類號 | 364.6 |
關鍵詞 | Hypusine; eIF-5A; Deoxyhypusine synthase; |
語文 | 英文(English) |
英文摘要 | Hypusine, an unusual amino acid, is derived from the hydrolysis of eukaryotic initiation factor 5A (eIF-5A), the only cellular protein known to contain hypusine residue. Hypusine residue is formed through a spermidine-dependent posttranslational modification of eIF-5A at a specific lysine residue. Each mature eIF-5A molecule contains only one hypusine. Hypusine formation on eIF-5A is essential for cell survival and proliferation. The biochemistry of hypusine formation has been actively investigated in a number of leading laboratories during the past decade. The precise functional role of eIF-5A remains a mystery. This paper reviews recent progress in the study of the biochemistry of hypusine formation and offers speculation on the possible function of eIF-5A. |
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