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題名 | 核研所鎝-99m-MAG[feb0]腎功能診斷核醫藥物之臨床評估=Clinical Evaluation of Renal Function with [fee6]Tc-MAG[feb0]Prepared from INER Mertiatide Kit |
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作者 | 蔡世傳; 林萬鈺; 廖美秀; 王世楨; 魏孝萍; 沈立漢; 丁幹; | 書刊名 | 核子醫學雜誌 |
卷期 | 12:1 1999.01[民88.01] |
頁次 | 頁7-11 |
分類號 | 418.346 |
關鍵詞 | 鎝-99m-MAG[feb0]; 碘-131-OIH; 有效腎血流量; [fee6]Tc-MAG[feb0]; [fef3]I-OIH; Effective renal plasma flow; |
語文 | 中文(Chinese) |
中文摘要 | 前言:多年來國內核醫界普遍使用碘-I31馬尿酸(碘-131-OlH)進行有效腎血流量之檢查。由於碘-131釋放之加馬射線能量較高,造影效果不佳,且會釋出貝它粒子,使受檢者吸收較高的輻射劑量。國內核能研究所已研發出可供製備鎝-99m-MAG□的組套,用以取代碘-131-OIH。本研究以核研所組套製備鎝-99m-MAG□製劑,對正常人及病患進行有效腎血流量測之臨床可用性評估。 材料與方法:本研究共收集12名正常人(9男,3女;年齡:37.0±12.4歲)及28名經確定或高度懷疑有泌尿道疾患之病患(14男,14女;年齡:55.5±16.5歲)進行研究。所有受試者皆分別接受鎝-99m-MAG□及碘-131-OlH兩種製劑之腎功能檢查,並以單次抽血方式算有效腎血流清除率,以直線迴歸及相關統計法比較鎝-99m-MAC□與碘-131-OlH結果。 結果:研究結果發現以單次抽血方式計算有效腎血流清除率,鎝-99m-MAG□與碘-131-OIH所得結果之直線迴歸函數為OIH=109.25+1.3693xMAG□(相關係數r值為0.814)。 結論:研究結果顯示核研所鎝-99m-MAG□製劑以單次抽血方式評估有效腎血流清除率與碘-131-OIH單次抽血方式所得之結果呈現相當好的相關性,支持核研所鎝-99m-MAG□用以評估有效腎血流量的臨床可用性。 |
英文摘要 | Backgrounds: □I labeled orthoiodohippurate (OIH) have been used for renal tubular function study for many years. The β-particle emission associated with the decay of □I not only increases absorbed radiation dose in patients, but also reduces the quality of scintigraphic imaging. Recently, another new radiopharmaceutical □ Tc-MAG□ prepared from INER Mertiatide kit has been developed, and may probably replace some of the applications of □I-OIH for renal tubular function evaluation. Material & Methods: In this study, 12 normal volunteers (9 males, 3 females; age: 37.0 ± 12.4 years) and 28 (14 males, 14 females; age: 55.5±16.5 years) adults with or highly-suspected renal function disorder (renal stone, chronic renal insufficiency, etc.) were enrolled to compare INER □Tc-MAG□ with □I-OIH in the efficacy of effective renal plasma flow determination. Each volunteer or patient was administered 10 mCi of □Tc-MAG□ for the first study and 300 μCi of □I-OIH for the second study. Dynamic images were collected with a gamma camera for 30 min. In addition, a single blood sample was drawn at 44 min post-injection in each study. Results: The results reveal a good correlation between these two agents with ERPF calculated by the single blood sampling method (r=0.814). Conclusions: Through this study, we can confirm the usefulness and the effectiveness of INER Mertiatide kits for clinical evaluation of ERPF by single blood sampling method. |
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