查詢結果分析
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頁籤選單縮合
題名 | Clinical Performance of the Levonorgestrel Intrauterine Contraceptive Device (Mirena[feb9]) and its Effect on Menorrhagia in Taiwanese Women=臺灣婦女使用Levonorgestrel避孕器於避孕與月經過多的經驗 |
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作 者 | 吳明義; 何弘能; 趙光漢; 陳欽德; 楊友仕; 李鎡堯; | 書刊名 | 中華民國婦產科醫學會會刊雜誌 |
卷期 | 38:4 1999.12[民88.12] |
頁次 | 頁131-139 |
分類號 | 417.129 |
關鍵詞 | 避孕器; 月經過多; 米瑞娜; Contraception; Intrauterine contraceptive device; Levonorgestrel; Menorrhagia; Mirena[feb9]; |
語文 | 英文(English) |
中文摘要 | 目的:瞭解含levonorgestrel黃體素的避孕器Mirena�麂洏峏韞x灣婦女身上,對於避孕與月經過多的影響。 方法:我們於1995年11月至1997年11月,追蹤臨床測試的64位志願者一年,分別於裝置後一個半月、三個月、六個月與十二個月回來追蹤。 結果:總共43位病人完成全程臨床測試,沒有一位懷孕。在六個月與一年追蹤時,血色素都有明顯增加,尤其是原來就有月經過多者。肝功能檢查方面,膽色素與LDH輕微升高,但膽固醇與三酸甘油脂有下降。最大的副作用為子宮點狀出血天數的延長,約佔七成;此外,陰道分泌物增加,青春痘產生與掉頭髮,下腹或下背疼痛約佔二至四成。沒有完成測試最主要的原因為陰道點狀出血。 結論:此避孕器避孕效果良好,副作用為陰道點狀出血,與一些雄性素有關的副作用,但是對於月經過多或經痛的婦女,不失為一個良好的選擇。 |
英文摘要 | OBJECTIVE: To verify the contraceptive effect of a levonorgestrel intrauterine device (IUD) (Mirena��, 20 ug/day) and evaluate its effect on menorrhagia in Taiwanese women. METHODS: We performed an open-label, non-comparative clinical trial in 64 patients for 12 months. An IUD, Mirena, was studied in 64 women from November 1995 to November 1997. All of the volunteers made clinic visits 1.5, 3, 6, and 12 months after the insertion of the Mirenia�� IUD with informed consent. RESULTS: Forty-three women completed this study and no one became pregnant during the period. Hemoglobin levels were significantly increased 6 and 12 months after IUD insertion, especially in the group with hypermenorrhea. Platelet count also decreased 12 months after insertion. Blood biochemistry showed elevated bilirubin and lactate dehydrogenase levels but decreased cholesterol and triglyceride levels throughout the clinical trial. The most common side effect was abnormal uterine bleeding (70.5%) with spotting for a long period of time. The symptoms of vaginal discharge, androgen-related hair loss or acne formation, and lower abdominal cramping pain or low back pain occurred in 27 to 43%, 20 to 30%, and 23 to 36% of the women respectively. CONCLUSION: This study demonstrated that the Mirena�� IUD 1) has a good contraceptive effect, 2) has the main side effect of vaginal spotting, 3) has some androgen-related side effects, 4) is most beneficial for those patients with hypermenorrhea, and 5) provides an alternative treatment for those with dysmenorrhea. |
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